TY - JOUR
T1 - Hepatocellular carcinoma in a patient with focal nodular hyperplasia
AU - Coopersmith, Craig M.
AU - Lowell, Jeffrey A.
AU - Hassan, Anjum
AU - Howard, Todd K.
N1 - Funding Information:
The authors would like to thank Walter Clemont for technical assistance. This work was partially supported by funding from the National Institutes of Health (GM000709).
PY - 2002
Y1 - 2002
N2 - Background: Focal nodular hyperplasia is an uncommon liver tumour that typically requires no therapeutic intervention. Case outline: A 43-year-old woman with a 20-year history of oral contraceptive use presented with symptomatic bilateral liver masses. Biopsy revealed hepatocellular carcinoma in the right hemiliver and focal nodular hyperplasia in the left hemiliver. At operation, the patient was noted to have multiple liver nodules bilaterally, and all intraoperative biopsies were consistent with focal nodular hyperplasia including a biopsy taken from the region that demonstrated carcinoma preoperatively. Because of the earlier biopsy results and the patient's preoperative symptoms, a right hemihepatectomy was performed. Final pathology revealed hepatocellular carcinoma directly adjacent to an area of focal nodular hyperplasia, as well as multiple other areas of hyperplastic liver tumour. Discussion: Although focal nodular hyperplasia is believed to be benign, few studies have followed patients with this tumour beyond three years. Longer-term follow-up studies are needed to determine the natural history of focal nodular hyperplasia, potentially focussing on a subset of patients with either diffuse tumours or prolonged oral contraceptive use.
AB - Background: Focal nodular hyperplasia is an uncommon liver tumour that typically requires no therapeutic intervention. Case outline: A 43-year-old woman with a 20-year history of oral contraceptive use presented with symptomatic bilateral liver masses. Biopsy revealed hepatocellular carcinoma in the right hemiliver and focal nodular hyperplasia in the left hemiliver. At operation, the patient was noted to have multiple liver nodules bilaterally, and all intraoperative biopsies were consistent with focal nodular hyperplasia including a biopsy taken from the region that demonstrated carcinoma preoperatively. Because of the earlier biopsy results and the patient's preoperative symptoms, a right hemihepatectomy was performed. Final pathology revealed hepatocellular carcinoma directly adjacent to an area of focal nodular hyperplasia, as well as multiple other areas of hyperplastic liver tumour. Discussion: Although focal nodular hyperplasia is believed to be benign, few studies have followed patients with this tumour beyond three years. Longer-term follow-up studies are needed to determine the natural history of focal nodular hyperplasia, potentially focussing on a subset of patients with either diffuse tumours or prolonged oral contraceptive use.
KW - Focal nodular hyperplasia
KW - Hepatocellular carcinoma
KW - Liver tumour
UR - http://www.scopus.com/inward/record.url?scp=0036408869&partnerID=8YFLogxK
U2 - 10.1080/136518202760388046
DO - 10.1080/136518202760388046
M3 - Article
C2 - 18332941
AN - SCOPUS:0036408869
SN - 1365-182X
VL - 4
SP - 135
EP - 138
JO - HPB
JF - HPB
IS - 3
ER -