Hepatocellular adenomas: Understanding the pathomolecular lexicon, MRI features, terminology, and pitfalls to inform a standardized approach

Maria Zulfiqar; Claude B. Sirlin; Norihide Yoneda; Maxime Ronot; Elizabeth M. Hecht; Victoria Chernyak; Osamu Matsui; Nina Bastati; Ahmed Ba-Ssalamah; Deyali Chatterjee; Mustafa Bashir; Kathryn J. Fowler

doi:10.1002/jmri.26902

Hepatocellular adenomas: Understanding the pathomolecular lexicon, MRI features, terminology, and pitfalls to inform a standardized approach

Maria Zulfiqar, Claude B. Sirlin, Norihide Yoneda, Maxime Ronot, Elizabeth M. Hecht, Victoria Chernyak, Osamu Matsui, Nina Bastati, Ahmed Ba-Ssalamah, Deyali Chatterjee, Mustafa Bashir, Kathryn J. Fowler

Section of Abdominal Imaging

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Hepatocellular adenomas (HCAs) are benign hepatic tumors that can be complicated by bleeding and/or malignant transformation. The epidemiology of HCAs has changed over recent decades, primarily influenced by an increased incidence of obesity in both men and women. Currently, at least eight distinct pathomolecular subtypes of HCAs have been identified, several of which have distinguishing and pertinent imaging features on MRI. Emerging evidence suggests that hepatobiliary phase appearance may provide diagnostic and prognostic information. The purpose of this article is to review the current pathomolecular lexicon and imaging features with emphasis on hepatobiliary phase appearance. Level of Evidence: 5. Technical Efficacy: Stage 3. J. Magn. Reson. Imaging 2020;51:1630–1640.

Original language	English
Pages (from-to)	1630-1640
Number of pages	11
Journal	Journal of Magnetic Resonance Imaging
Volume	51
Issue number	6
DOIs	https://doi.org/10.1002/jmri.26902
State	Published - Jun 1 2020

Keywords

HCA subtypes
MRI
hepatobiliary contrast imaging
hepatocellular adenoma

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10.1002/jmri.26902

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Zulfiqar, M., Sirlin, C. B., Yoneda, N., Ronot, M., Hecht, E. M., Chernyak, V., Matsui, O., Bastati, N., Ba-Ssalamah, A., Chatterjee, D., Bashir, M., & Fowler, K. J. (2020). Hepatocellular adenomas: Understanding the pathomolecular lexicon, MRI features, terminology, and pitfalls to inform a standardized approach. Journal of Magnetic Resonance Imaging, 51(6), 1630-1640. https://doi.org/10.1002/jmri.26902

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title = "Hepatocellular adenomas: Understanding the pathomolecular lexicon, MRI features, terminology, and pitfalls to inform a standardized approach",

abstract = "Hepatocellular adenomas (HCAs) are benign hepatic tumors that can be complicated by bleeding and/or malignant transformation. The epidemiology of HCAs has changed over recent decades, primarily influenced by an increased incidence of obesity in both men and women. Currently, at least eight distinct pathomolecular subtypes of HCAs have been identified, several of which have distinguishing and pertinent imaging features on MRI. Emerging evidence suggests that hepatobiliary phase appearance may provide diagnostic and prognostic information. The purpose of this article is to review the current pathomolecular lexicon and imaging features with emphasis on hepatobiliary phase appearance. Level of Evidence: 5. Technical Efficacy: Stage 3. J. Magn. Reson. Imaging 2020;51:1630–1640.",

keywords = "HCA subtypes, MRI, hepatobiliary contrast imaging, hepatocellular adenoma",

author = "Maria Zulfiqar and Sirlin, {Claude B.} and Norihide Yoneda and Maxime Ronot and Hecht, {Elizabeth M.} and Victoria Chernyak and Osamu Matsui and Nina Bastati and Ahmed Ba-Ssalamah and Deyali Chatterjee and Mustafa Bashir and Fowler, {Kathryn J.}",

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Zulfiqar, M, Sirlin, CB, Yoneda, N, Ronot, M, Hecht, EM, Chernyak, V, Matsui, O, Bastati, N, Ba-Ssalamah, A, Chatterjee, D, Bashir, M & Fowler, KJ 2020, 'Hepatocellular adenomas: Understanding the pathomolecular lexicon, MRI features, terminology, and pitfalls to inform a standardized approach', Journal of Magnetic Resonance Imaging, vol. 51, no. 6, pp. 1630-1640. https://doi.org/10.1002/jmri.26902

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T1 - Hepatocellular adenomas

T2 - Understanding the pathomolecular lexicon, MRI features, terminology, and pitfalls to inform a standardized approach

AU - Zulfiqar, Maria

AU - Sirlin, Claude B.

AU - Yoneda, Norihide

AU - Ronot, Maxime

AU - Hecht, Elizabeth M.

AU - Chernyak, Victoria

AU - Matsui, Osamu

AU - Bastati, Nina

AU - Ba-Ssalamah, Ahmed

AU - Chatterjee, Deyali

AU - Bashir, Mustafa

AU - Fowler, Kathryn J.

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Hepatocellular adenomas (HCAs) are benign hepatic tumors that can be complicated by bleeding and/or malignant transformation. The epidemiology of HCAs has changed over recent decades, primarily influenced by an increased incidence of obesity in both men and women. Currently, at least eight distinct pathomolecular subtypes of HCAs have been identified, several of which have distinguishing and pertinent imaging features on MRI. Emerging evidence suggests that hepatobiliary phase appearance may provide diagnostic and prognostic information. The purpose of this article is to review the current pathomolecular lexicon and imaging features with emphasis on hepatobiliary phase appearance. Level of Evidence: 5. Technical Efficacy: Stage 3. J. Magn. Reson. Imaging 2020;51:1630–1640.

AB - Hepatocellular adenomas (HCAs) are benign hepatic tumors that can be complicated by bleeding and/or malignant transformation. The epidemiology of HCAs has changed over recent decades, primarily influenced by an increased incidence of obesity in both men and women. Currently, at least eight distinct pathomolecular subtypes of HCAs have been identified, several of which have distinguishing and pertinent imaging features on MRI. Emerging evidence suggests that hepatobiliary phase appearance may provide diagnostic and prognostic information. The purpose of this article is to review the current pathomolecular lexicon and imaging features with emphasis on hepatobiliary phase appearance. Level of Evidence: 5. Technical Efficacy: Stage 3. J. Magn. Reson. Imaging 2020;51:1630–1640.

KW - HCA subtypes

KW - MRI

KW - hepatobiliary contrast imaging

KW - hepatocellular adenoma

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JF - Journal of Magnetic Resonance Imaging

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ER -

Hepatocellular adenomas: Understanding the pathomolecular lexicon, MRI features, terminology, and pitfalls to inform a standardized approach

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