TY - JOUR
T1 - Hepatic mucormycosis mimicking veno-occlusive disease
T2 - Report of a case and review of the literature
AU - Yang, Chen
AU - Friess, Stuart H.
AU - Dehner, Louis P.
N1 - Publisher Copyright:
© 2016 Society for Pediatric Pathology.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - The clinical history of a 12-year-old boy with trisomy 21 who suffered from relapsed pre-B cell acute lymphocytic leukemia with clinical symptoms of hepatic veno-occlusive disease and death is reported. The postmortem findings were significant for hepatic mucormycosis with selective involvement of the central veins, sinusoids, and portal tracts resulting in obstruction of the outflow tract and massive hepatocellular necrosis. Hematogenous dissemination of mucormycosis causing acute splenitis and hemorrhagic intestinal necrosis were also observed. To our knowledge, mucormycosis invasion of the central veins, sinusoids, and portal tracts by fungal hyphae resulting in a syndrome mimicking hepatic veno-occlusive disease has not been previously reported.
AB - The clinical history of a 12-year-old boy with trisomy 21 who suffered from relapsed pre-B cell acute lymphocytic leukemia with clinical symptoms of hepatic veno-occlusive disease and death is reported. The postmortem findings were significant for hepatic mucormycosis with selective involvement of the central veins, sinusoids, and portal tracts resulting in obstruction of the outflow tract and massive hepatocellular necrosis. Hematogenous dissemination of mucormycosis causing acute splenitis and hemorrhagic intestinal necrosis were also observed. To our knowledge, mucormycosis invasion of the central veins, sinusoids, and portal tracts by fungal hyphae resulting in a syndrome mimicking hepatic veno-occlusive disease has not been previously reported.
KW - Mucormycosis
KW - Sinusoidal obstructive syndrome
KW - Veno-occlusive disease
UR - http://www.scopus.com/inward/record.url?scp=84964052748&partnerID=8YFLogxK
U2 - 10.2350/15-06-1661-CR.1
DO - 10.2350/15-06-1661-CR.1
M3 - Review article
C2 - 26366930
AN - SCOPUS:84964052748
SN - 1093-5266
VL - 19
SP - 150
EP - 153
JO - Pediatric and Developmental Pathology
JF - Pediatric and Developmental Pathology
IS - 2
ER -