Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome

Keyphrases

• Bisphosphonates 16%
• Chemical Profiling 16%
• CoA Synthase 16%
• Cycle Flux 33%
• Cycle Oxidation 16%
• Disease Drivers 16%
• Energy Charge 33%
• Energy Homeostasis 33%
• Fat Oxidation 16%
• Fed State 66%
• Fold Increase 16%
• Glucose Metabolism 16%
• Glycogen Metabolism 100%
• Glycogenolysis 16%
• Hepatic Glucose Production 66%
• Hepatic Glycogen 100%
• High-fat Diet 16%
• High-fat Diet Mice 16%
• High-resolution 16%
• HMGCS2 16%
• Hydroxymethylglutaryl-CoA 16%
• Ketogenesis 100%
• Ketogenic 100%
• Knockdown 16%
• Lipidome 100%
• Liver 66%
• Mitochondrial Isoforms 16%
• Molecular Targets 16%
• Mouse Model 33%
• NMR Spectroscopy 16%
• Non-alcoholic Fatty Liver Disease (NAFLD) 50%
• Nonalcoholic Steatohepatitis 16%
• Partial Oxidation 16%
• Profiling Technology 16%
• Shotgun Lipidomics 16%
• Stable Isotope Tracers 16%
• Tricarboxylic Acid Cycle (TCA cycle) 50%
• Untargeted Metabolomics 16%
• Wild Mice 16%

Biochemistry, Genetics and Molecular Biology

• Citric Acid Cycle 50%
• Energy Charge 33%
• Gluconeogenesis 66%
• Glucose Metabolism 16%
• Glycogen Liver Level 100%
• Glycogen Metabolism 100%
• Glycogenolysis 16%
• Homeostasis 33%
• Isoform 16%
• Ketogenesis 100%
• Lipidome 100%
• Lipidomics 16%
• Metabolomics 16%
• Mouse Model 33%
• Nuclear Magnetic Resonance Spectroscopy 16%
• Synthase 16%
• Wild Type Mouse 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Lipidome 100%
• Molecular Target 25%
• Mouse Model 50%
• Nonalcoholic Fatty Liver 100%
• Stable Isotope 25%
• Synthetase 25%
• Tracer 25%
• Tricarboxylic Acid 75%
• Wild Type Mouse 25%