TY - JOUR
T1 - Hepatic expression of cell death-inducing DFFA-like effector C in obese subjects is reduced by marked weight loss
AU - Hall, Angela M.
AU - Brunt, Elizabeth M.
AU - Klein, Samuel
AU - Finck, Brian N.
PY - 2010/2
Y1 - 2010/2
N2 - The hepatic expression of the cell death-inducing DNA fragmentation factor A-like effector family (CIDEA, CIDEB, and CIDEC) genes is markedly upregulated in mouse models of obesity. We evaluated the expression of CIDE genes in liver of obese human subjects undergoing gastric bypass surgery (GBS), at the time of surgery and again 1 year later when subjects had lost 37.6 ± 1.4% of their initial body weight. At the time of GBS, the expression of CIDEA (r 2 = 0.20, P = 0.04) and CIDEC (r 2 = 0.32, P = 0.01) was strongly correlated with BMI, whereas CIDEB was not (r 2 = 0.01, P = 0.81). One year after surgery, CIDEC expression had declined over 60% (P = 0.02), whereas CIDEA expression did not change (P = 0.20). These data demonstrate that, consistent with previous studies conducted in rodents, hepatic expression of CIDEA and CIDEC, but not CIDEB, is increased in obese humans. Moreover, the hepatic expression of CIDEC is downregulated by marked weight loss.
AB - The hepatic expression of the cell death-inducing DNA fragmentation factor A-like effector family (CIDEA, CIDEB, and CIDEC) genes is markedly upregulated in mouse models of obesity. We evaluated the expression of CIDE genes in liver of obese human subjects undergoing gastric bypass surgery (GBS), at the time of surgery and again 1 year later when subjects had lost 37.6 ± 1.4% of their initial body weight. At the time of GBS, the expression of CIDEA (r 2 = 0.20, P = 0.04) and CIDEC (r 2 = 0.32, P = 0.01) was strongly correlated with BMI, whereas CIDEB was not (r 2 = 0.01, P = 0.81). One year after surgery, CIDEC expression had declined over 60% (P = 0.02), whereas CIDEA expression did not change (P = 0.20). These data demonstrate that, consistent with previous studies conducted in rodents, hepatic expression of CIDEA and CIDEC, but not CIDEB, is increased in obese humans. Moreover, the hepatic expression of CIDEC is downregulated by marked weight loss.
UR - http://www.scopus.com/inward/record.url?scp=75749103353&partnerID=8YFLogxK
U2 - 10.1038/oby.2009.236
DO - 10.1038/oby.2009.236
M3 - Article
C2 - 19661960
AN - SCOPUS:75749103353
SN - 1930-7381
VL - 18
SP - 417
EP - 419
JO - Obesity
JF - Obesity
IS - 2
ER -