TY - JOUR
T1 - Hemostatic spray powder TC-325 in the primary endoscopic treatment of peptic ulcer-related bleeding
T2 - Multicenter international registry
AU - Hussein, Mohamed
AU - Alzoubaidi, Durayd
AU - Lopez, Miguel Fraile
AU - Weaver, Michael
AU - Ortiz-Fernandez-Sordo, Jacobo
AU - Bassett, Paul
AU - Rey, Johannes W.
AU - Hayee, Bu Hussain
AU - Despott, Edward
AU - Murino, Alberto
AU - Moreea, Sulleman
AU - Boger, Philip
AU - Dunn, Jason
AU - Mainie, Inder
AU - Graham, David
AU - Mullady, Daniel K.
AU - Early, Dayna S.
AU - Ragunath, Krish
AU - Anderson, John T.
AU - Bhandari, Pradeep
AU - Goetz, Martin
AU - Kiesslich, Ralf
AU - Coron, Emmanuel
AU - Lovat, Laurence B.
AU - Haidry, Rehan
N1 - Publisher Copyright:
© 2021 Georg Thieme Verlag. All rights reserved.
PY - 2020/12/17
Y1 - 2020/12/17
N2 - Background Upper gastrointestinal bleeding (UGIB) is a leading cause of morbidity and is associated with a 2 % - 17 % mortality rate in the UK and USA. Bleeding peptic ulcers account for 50 % of UGIB cases. Endoscopic intervention in a timely manner can improve outcomes. Hemostatic spray is an endoscopic hemostatic powder for GI bleeding. This multicenter registry was created to collect data prospectively on the immediate endoscopic hemostasis of GI bleeding in patients with peptic ulcer disease when hemostatic spray is applied as endoscopic monotherapy, dual therapy, or rescue therapy. Methods Data were collected prospectively (January 2016 - March 2019) from 14 centers in the UK, France, Germany, and the USA. The application of hemostatic spray was decided upon at the endoscopist's discretion. Results 202 patients with UGIB secondary to peptic ulcers were recruited. Immediate hemostasis was achieved in 178/202 patients (88 %), 26/154 (17 %) experienced rebleeding, 21/175 (12 %) died within 7 days, and 38/175 (22 %) died within 30 days (all-cause mortality). Combination therapy of hemostatic spray with other endoscopic modalities had an associated lower 30-day mortality (16 %, P < 0.05) compared with monotherapy or rescue therapy. There were high immediate hemostasis rates across all peptic ulcer disease Forrest classifications. Conclusions This is the largest case series of outcomes of peptic ulcer bleeding treated with hemostatic spray, with high immediate hemostasis rates for bleeding peptic ulcers.
AB - Background Upper gastrointestinal bleeding (UGIB) is a leading cause of morbidity and is associated with a 2 % - 17 % mortality rate in the UK and USA. Bleeding peptic ulcers account for 50 % of UGIB cases. Endoscopic intervention in a timely manner can improve outcomes. Hemostatic spray is an endoscopic hemostatic powder for GI bleeding. This multicenter registry was created to collect data prospectively on the immediate endoscopic hemostasis of GI bleeding in patients with peptic ulcer disease when hemostatic spray is applied as endoscopic monotherapy, dual therapy, or rescue therapy. Methods Data were collected prospectively (January 2016 - March 2019) from 14 centers in the UK, France, Germany, and the USA. The application of hemostatic spray was decided upon at the endoscopist's discretion. Results 202 patients with UGIB secondary to peptic ulcers were recruited. Immediate hemostasis was achieved in 178/202 patients (88 %), 26/154 (17 %) experienced rebleeding, 21/175 (12 %) died within 7 days, and 38/175 (22 %) died within 30 days (all-cause mortality). Combination therapy of hemostatic spray with other endoscopic modalities had an associated lower 30-day mortality (16 %, P < 0.05) compared with monotherapy or rescue therapy. There were high immediate hemostasis rates across all peptic ulcer disease Forrest classifications. Conclusions This is the largest case series of outcomes of peptic ulcer bleeding treated with hemostatic spray, with high immediate hemostasis rates for bleeding peptic ulcers.
UR - http://www.scopus.com/inward/record.url?scp=85098194726&partnerID=8YFLogxK
U2 - 10.1055/a-1186-5360
DO - 10.1055/a-1186-5360
M3 - Article
C2 - 32459000
AN - SCOPUS:85098194726
SN - 0013-726X
VL - 53
SP - 36
EP - 43
JO - Endoscopy
JF - Endoscopy
IS - 1
ER -