Hemolytic uremic syndrome presenting after treatment of endodermal sinus tumor

Dele A. Ogunleye, Sharyn N. Lewin, David G. Mutch, Helen Liapis, Thomas J. Herzog

Research output: Contribution to journalArticlepeer-review


BACKGROUND:: Hemolytic uremic syndrome is a rare multisystem disorder that is caused by infections, preeclampsia, autoimmune disorders, or oral contraceptive agents, and rarely in association with different cancers and chemotherapeutic agents. CASE:: A 34-year-old woman who presented for evaluation of a pelvic mass received a diagnosis of International Federation of Gynecology and Obstetrics (FIGO) stage 1c endodermal sinus tumor at laparotomy. Three months after receiving 3 courses of bleomycin, etoposide, and cisplatinum, she presented with renal failure, thrombocytopenia, anemia, and severe hypertension. Cancer-associated hemolytic uremic syndrome was diagnosed, and the patient was treated with plasmaphoresis, blood transfusion, and hemodialysis. CONCLUSION:: Cancer-associated hemolytic uremic syndrome has a high mortality rate; thus, prompt diagnosis is critical to survival.

Original languageEnglish
Pages (from-to)1184-1187
Number of pages4
JournalObstetrics and gynecology
Issue number5 PART 2
StatePublished - Nov 1 2004


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