Hemolytic uremic syndrome in an adolescent with Fusobacterium necrophorum bacteremia.

D. H. Chand, R. C. Brady, J. J. Bissler

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Microorganisms may produce substances that disrupt the interaction between platelets and vascular endothelium, which has been associated with atypical hemolytic uremic syndrome (HUS). We present the first reported case of Fusobacterium necrophorum bacteremia that presented initially with atypical HUS. Antimicrobial therapy eradicated the patient's bacteremia, and plasmapheresis restored platelet-endothelial homeostasis. Understanding the pathophysiologic mechanisms involved in atypical HUS would guide the development of more precise therapies.

Original languageEnglish
Pages (from-to)E22
JournalAmerican journal of kidney diseases : the official journal of the National Kidney Foundation
Volume37
Issue number3
StatePublished - Mar 2001
Externally publishedYes

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