Hemolytic Uremic Syndrome

Ellen M. Cody, Bradley P. Dixon

Research output: Contribution to journalReview articlepeer-review

72 Scopus citations

Abstract

Hemolytic uremic syndrome (HUS) is the clinical triad of thrombocytopenia, anemia, and acute kidney injury. Classically associated with enterocolitis from Shiga toxin–producing Escherichia coli, HUS is also associated with Streptococcus pneumoniae infections; genetic dysregulation of the alternative complement pathway or coagulation cascade; and, rarely, a hereditary disorder of cobalamin C metabolism. These share a common final pathway of a prothrombotic and proinflammatory state on the endothelial cell surface, with fibrin and platelet deposition. Much work has been done to distinguish between the different mechanisms of disease, thereby informing the optimal therapeutic interventions for each entity.

Original languageEnglish
Pages (from-to)235-246
Number of pages12
JournalPediatric Clinics of North America
Volume66
Issue number1
DOIs
StatePublished - Feb 2019

Keywords

  • Atypical HUS
  • Cobalamin C
  • Escherichia coli
  • Hemolytic uremic syndrome
  • Pneumococcal HUS
  • Shiga toxin

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