Hemodynamic responses to antivascular therapy and ionizing radiation assessed by diffuse optical spectroscopies

Ulas Sunar, Sosina Makonnen, Chao Zhou, Turgut Durduran, Guoqiang Yu, Hsing Wen Wang, William M.F. Lee, Arjun G. Yodh

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Diffuse optical methods were used to monitor two different therapies in K1735 malignant mouse melanoma tumor models: anti-vascular therapy and radiation therapy. Anti-vascular therapy induced acute variation in hemodynamic parameters within an hour, and radiation therapy induced longitudinal changes within 2 weeks. During anti-vascular therapy, the drug Combretastatin A-4 3-O-Phosphate (CA4P, 2.5 mg/200 μl PBS/mouse) significantly decreased tissue blood flow (65%) and blood oxygenation (38%) one hour after injection. In the longitudinal study, single-fraction ionizing radiation (12 Gy × 1) induced significant reduction of tissue blood flow (36%) and blood oxygenation (24%) 14 days after radiation. The results correlated well with contrast enhanced ultrasound, tumor histology, and a nitroimidazole hypoxia marker (EF5). The research provides further evidence that noninvasive diffuse optical spectroscopies can be useful tools for monitoring cancer therapy in vivo.

Original languageEnglish
Pages (from-to)15507-15516
Number of pages10
JournalOptics Express
Volume15
Issue number23
DOIs
StatePublished - Nov 12 2007

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