Hemodynamic Performance and Thrombogenic Properties of a Superhydrophobic Bileaflet Mechanical Heart Valve

David L. Bark, Hamed Vahabi, Hieu Bui, Sanli Movafaghi, Brandon Moore, Arun K. Kota, Ketul Popat, Lakshmi P. Dasi

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

In this study, we explore how blood-material interactions and hemodynamics are impacted by rendering a clinical quality 25 mm St. Jude Medical Bileaflet mechanical heart valve (BMHV) superhydrophobic (SH) with the aim of reducing thrombo-embolic complications associated with BMHVs. Basic cell adhesion is evaluated to assess blood-material interactions, while hemodynamic performance is analyzed with and without the SH coating. Results show that a SH coating with a receding contact angle (CA) of 160° strikingly eliminates platelet and leukocyte adhesion to the surface. Alternatively, many platelets attach to and activate on pyrolytic carbon (receding CA = 47), the base material for BMHVs. We further show that the performance index increases by 2.5% for coated valve relative to an uncoated valve, with a maximum possible improved performance of 5%. Both valves exhibit instantaneous shear stress below 10 N/m2 and Reynolds Shear Stress below 100 N/m2. Therefore, a SH BMHV has the potential to relax the requirement for antiplatelet and anticoagulant drug regimens typically required for patients receiving MHVs by minimizing blood-material interactions, while having a minimal impact on hemodynamics. We show for the first time that SH-coated surfaces may be a promising direction to minimize thrombotic complications in complex devices such as heart valves.

Original languageEnglish
Pages (from-to)452-463
Number of pages12
JournalAnnals of biomedical engineering
Volume45
Issue number2
DOIs
StatePublished - Feb 1 2017

Keywords

  • Bileaflet mechanical heart valve
  • Blood
  • Shear stress
  • Superhydrophobic
  • Thrombosis
  • Turbulence

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