TY - JOUR
T1 - Hemodynamic Consequences of Right Ventricular Isolation
T2 - The Contribution of the Right Ventricular Free Wall to Cardiac Performance
AU - Damiano, Ralph J.
AU - Asano, Tetsuo
AU - Smith, Peter K.
AU - Ferguson, T. Bruce
AU - Cox, James L.
N1 - Funding Information:
Supported by National Institutes of Health Grant HL 32257, ROI-HL-32257. We acknowledge the technical assistance of George Quick and Michael Lowe and the secretarial help of Ruth Dixon.
PY - 1988
Y1 - 1988
N2 - Surgical isolation of the right ventricular free wall was performed in 10 dogs to evaluate both the hemodynamic effects of the procedure and the postoperative contribution of right ventricular free wall contraction to overall cardiac performance. Following the procedure, there were no significant differences in peak right ventricular systolic pressure, right atrial pressure, right ventricular stroke volume, or cardiac index. Cardiac index remained at preoperative levels over a wide range of filling pressures. However, there was a significant decrease in right ventricular stroke work (6.0 ± 1.3 gm-m/m2 to 5.1 ± 0.5 gm-m/m2; p < 0.05). Pacing the isolated right ventricular free wall resulted in marked hemodynamic improvement compared with an electrically silent right ventricular free wall. Cardiac index increased from 1.7 ± 0.2 L/min/m2 to 2.6 ± 0.2 L/min/m2 (p < 0.0005), and right ventricular stroke work went from 3.0 ± 0.6 gm-m/m2 to 6.4 ± 0.9 gm-m/m2 (p < 0.0005). Right ventricular performance was also significantly related to the timing of right ventricular free wall contraction. Thus, the right ventricular free wall played an important role in the maintenance of normal cardiac hemodynamics.
AB - Surgical isolation of the right ventricular free wall was performed in 10 dogs to evaluate both the hemodynamic effects of the procedure and the postoperative contribution of right ventricular free wall contraction to overall cardiac performance. Following the procedure, there were no significant differences in peak right ventricular systolic pressure, right atrial pressure, right ventricular stroke volume, or cardiac index. Cardiac index remained at preoperative levels over a wide range of filling pressures. However, there was a significant decrease in right ventricular stroke work (6.0 ± 1.3 gm-m/m2 to 5.1 ± 0.5 gm-m/m2; p < 0.05). Pacing the isolated right ventricular free wall resulted in marked hemodynamic improvement compared with an electrically silent right ventricular free wall. Cardiac index increased from 1.7 ± 0.2 L/min/m2 to 2.6 ± 0.2 L/min/m2 (p < 0.0005), and right ventricular stroke work went from 3.0 ± 0.6 gm-m/m2 to 6.4 ± 0.9 gm-m/m2 (p < 0.0005). Right ventricular performance was also significantly related to the timing of right ventricular free wall contraction. Thus, the right ventricular free wall played an important role in the maintenance of normal cardiac hemodynamics.
UR - http://www.scopus.com/inward/record.url?scp=0023795216&partnerID=8YFLogxK
U2 - 10.1016/S0003-4975(10)65936-X
DO - 10.1016/S0003-4975(10)65936-X
M3 - Article
C2 - 3415377
AN - SCOPUS:0023795216
SN - 0003-4975
VL - 46
SP - 324
EP - 330
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 3
ER -