TY - JOUR
T1 - Hematopoietic mutations in the zebrafish
AU - Weinstein, Brant M.
AU - Schier, Alexander F.
AU - Abdelilah, Salim
AU - Malicki, Jarema
AU - Solnica-Krezel, Lilliana
AU - Stemple, Derek L.
AU - Stainier, Didier Y.R.
AU - Zwartkruis, Fried
AU - Driever, Wolfgang
AU - Fishman, Mark C.
PY - 1996
Y1 - 1996
N2 - We have identified mutations that perturb the formation or differentiation of the first embryonic blood cells in the zebrafish embryo. These 'primitive' red blood cells originate in the intermediate cell mass of the trunk, a derivative of the dorsal lateral plate mesoderm. By transfusion of blood between embryos we demonstrate that this cohort of cells provides the embryo with all, or nearly all, of its blood cells until at least day 5 postfertilization. Larval lethal mutations generated by ENU mutagenesis affect different steps in the development of these cells. Some cause defects in precursor generation, others defects in differentiation, and others an increase in cellular photosensitivity.
AB - We have identified mutations that perturb the formation or differentiation of the first embryonic blood cells in the zebrafish embryo. These 'primitive' red blood cells originate in the intermediate cell mass of the trunk, a derivative of the dorsal lateral plate mesoderm. By transfusion of blood between embryos we demonstrate that this cohort of cells provides the embryo with all, or nearly all, of its blood cells until at least day 5 postfertilization. Larval lethal mutations generated by ENU mutagenesis affect different steps in the development of these cells. Some cause defects in precursor generation, others defects in differentiation, and others an increase in cellular photosensitivity.
KW - Mutations
KW - Primitive haematopoiesis
KW - Zebrafish
UR - http://www.scopus.com/inward/record.url?scp=12644314123&partnerID=8YFLogxK
M3 - Article
C2 - 9007250
AN - SCOPUS:12644314123
SN - 0950-1991
VL - 123
SP - 303
EP - 309
JO - Development
JF - Development
ER -