Hematopoietic cell transplantation comorbidity index (HCT-CI) is predictive of adverse events and overall survival in older allogeneic transplant recipients

Jesse W. Keller, Charalambos Andreadis, Lloyd E. Damon, Lawrence D. Kaplan, Thomas G. Martin, Jeffrey L. Wolf, Weiyun Z. Ai, Jeffrey M. Venstrom, Catherine C. Smith, Karin M.L. Gaensler, Jimmy Hwang, Rebecca L. Olin

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Objectives: Our goal was to evaluate the ability of the hematopoietic cell transplantation comorbidity index (HCT-CI) to predict outcomes after allogeneic stem cell transplant (SCT) within the context of an older patient population, where multiple comorbidities are common. Materials and Methods: We performed a retrospective cohort study of SCT patients ≥ 50 years of age at our institution, identifying 59 patients with complete HCT-CI data collected prospectively. Results: HCT-CI category distribution in our sample was disproportionate, with almost half of patients having scores ≥ 3. High HCT-CI score (≥ 3 vs < 3) was associated with significantly inferior OS (median OS not reached for HCT-CI < 3 vs 14 months for HCT-CI ≥ 3; hazard ratio (HR) 2.2, p = 0.02). HCT-CI score was a better predictor of OS than age, performance status or conditioning intensity. When adjusted for disease relapse risk, HCT-CI score conferred a worse prognosis in the low risk group (HR 1.43, p = 0.03) but not in the intermediate/high risk group (HR 1.08, p = 0.65). NRM was low in the total sample (6% at one year) and was not associated with HCT-CI score. Grade 3-4 non-hematologic adverse events within the first 100. days after SCT were significantly more common in the higher HCT-CI groups (p = 0.02). Conclusions: In our older patient cohort with a high incidence of multiple comorbidities, HCT-CI score ≥ 3 was significantly associated with OS, particularly in the subset of patients with a low disease relapse risk.

Original languageEnglish
Pages (from-to)238-244
Number of pages7
JournalJournal of Geriatric Oncology
Volume5
Issue number3
DOIs
StatePublished - Jul 2014

Keywords

  • Allogeneic
  • Comorbidity
  • Elderly
  • Hematopoietic stem cell transplantation

Fingerprint

Dive into the research topics of 'Hematopoietic cell transplantation comorbidity index (HCT-CI) is predictive of adverse events and overall survival in older allogeneic transplant recipients'. Together they form a unique fingerprint.

Cite this