TY - JOUR
T1 - Hematopoiesis and the bacterial microbiome
AU - Yan, Hannah
AU - Baldridge, Megan T.
AU - King, Katherine Y.
N1 - Funding Information:
This work was supported by the National Institutes of Health, National Heart, Lung, and Blood Institute grants R01HL136333 and R01HL134880 (K.Y.K. and H.Y.), the Aplastic Anemia and MDS International Foundation Liviya Anderson Award (K.Y.K.), and a March of Dimes Basil O’Connor Starter Scholar Award (K.Y.K.). M.T.B. was supported by the Global Probiotics Council’s Young Investigator Grant for Probiotics Research. H.Y. is supported by National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases grant T32 DK060445.
Publisher Copyright:
© 2018 by The American Society of Hematology.
PY - 2018/8/9
Y1 - 2018/8/9
N2 - Recent studies have revealed that the intestinal bacterial microbiome plays an important role in the regulation of hematopoiesis. A correlation between adverse hematologic effects and imbalance of the intestinal microbiome, or dysbiosis, is evident in several human conditions, such as inflammatory bowel disease, obesity, and, critically, in the setting of antibiotic exposure. Here we review the effects of gut dysbiosis on the hematological compartment and our current understanding of the mechanisms through which changes in the bacterial microbiome affect hematopoiesis.
AB - Recent studies have revealed that the intestinal bacterial microbiome plays an important role in the regulation of hematopoiesis. A correlation between adverse hematologic effects and imbalance of the intestinal microbiome, or dysbiosis, is evident in several human conditions, such as inflammatory bowel disease, obesity, and, critically, in the setting of antibiotic exposure. Here we review the effects of gut dysbiosis on the hematological compartment and our current understanding of the mechanisms through which changes in the bacterial microbiome affect hematopoiesis.
UR - http://www.scopus.com/inward/record.url?scp=85051363474&partnerID=8YFLogxK
U2 - 10.1182/blood-2018-02-832519
DO - 10.1182/blood-2018-02-832519
M3 - Article
C2 - 29853538
AN - SCOPUS:85051363474
SN - 0006-4971
VL - 132
SP - 559
EP - 564
JO - Blood
JF - Blood
IS - 6
ER -