Hematologic side effects of biologics and kinase inhibitors used in rheumatologic diseases: a review of the current evidence

Sambhawana Bhandari; Maun Ranjan Baral; Matthew Barbery; Alla Rudinskaya; Oleg Sostin

doi:10.1007/s00277-022-04896-7

Hematologic side effects of biologics and kinase inhibitors used in rheumatologic diseases: a review of the current evidence

Sambhawana Bhandari, Maun Ranjan Baral, Matthew Barbery, Alla Rudinskaya, Oleg Sostin

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Treatment options for various rheumatologic diseases have been limited until the introduction of biologic agents and kinase inhibitor therapy in recent decades. Since their arrival, they have steadily been integrated into routine management. Given their wide use and overall successful outcomes, it becomes increasingly pertinent for clinicians to readily identify their side effects. Their effects can involve multiple organ systems, including hematologic. This review aims to identify and classify the range of hematologic effects associated with individual biologics and kinase inhibitors used for treatment of rheumatologic diseases.

Original language	English
Pages (from-to)	1897-1904
Number of pages	8
Journal	Annals of Hematology
Volume	101
Issue number	9
DOIs	https://doi.org/10.1007/s00277-022-04896-7
State	Published - Sep 2022

Keywords

Biologics
Co-stimulation blockers
Cytokine inhibitors
Hematologic side effects
Kinase inhibitors

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10.1007/s00277-022-04896-7

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title = "Hematologic side effects of biologics and kinase inhibitors used in rheumatologic diseases: a review of the current evidence",

abstract = "Treatment options for various rheumatologic diseases have been limited until the introduction of biologic agents and kinase inhibitor therapy in recent decades. Since their arrival, they have steadily been integrated into routine management. Given their wide use and overall successful outcomes, it becomes increasingly pertinent for clinicians to readily identify their side effects. Their effects can involve multiple organ systems, including hematologic. This review aims to identify and classify the range of hematologic effects associated with individual biologics and kinase inhibitors used for treatment of rheumatologic diseases.",

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author = "Sambhawana Bhandari and Baral, {Maun Ranjan} and Matthew Barbery and Alla Rudinskaya and Oleg Sostin",

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AU - Baral, Maun Ranjan

AU - Barbery, Matthew

AU - Rudinskaya, Alla

AU - Sostin, Oleg

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N2 - Treatment options for various rheumatologic diseases have been limited until the introduction of biologic agents and kinase inhibitor therapy in recent decades. Since their arrival, they have steadily been integrated into routine management. Given their wide use and overall successful outcomes, it becomes increasingly pertinent for clinicians to readily identify their side effects. Their effects can involve multiple organ systems, including hematologic. This review aims to identify and classify the range of hematologic effects associated with individual biologics and kinase inhibitors used for treatment of rheumatologic diseases.

AB - Treatment options for various rheumatologic diseases have been limited until the introduction of biologic agents and kinase inhibitor therapy in recent decades. Since their arrival, they have steadily been integrated into routine management. Given their wide use and overall successful outcomes, it becomes increasingly pertinent for clinicians to readily identify their side effects. Their effects can involve multiple organ systems, including hematologic. This review aims to identify and classify the range of hematologic effects associated with individual biologics and kinase inhibitors used for treatment of rheumatologic diseases.

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KW - Co-stimulation blockers

KW - Cytokine inhibitors

KW - Hematologic side effects

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ER -

Hematologic side effects of biologics and kinase inhibitors used in rheumatologic diseases: a review of the current evidence

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