Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation

Jiani N. Chai, Yangqing Peng, Sunaina Rengarajan, Benjamin D. Solomon, Teresa L. Ai, Zeli Shen, Justin S.A. Perry, Kathryn A. Knoop, Takeshi Tanoue, Seiko Narushima, Kenya Honda, Charles O. Elson, Rodney D. Newberry, Thaddeus S. Stappenbeck, Andrew L. Kau, Daniel A. Peterson, James G. Fox, Chyi Song Hsieh

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Specific gut commensal bacteria improve host health by eliciting mutualistic regulatory T (Treg) cell responses. However, the bacteria that induce effector T (Teff) cells during inflammation are unclear. We addressed this by analyzing bacterial-reactive T cell receptor (TCR) transgenic cells and TCR repertoires in a murine colitis model. Unexpectedly, we found that mucosal-associated Helicobacter species triggered both Treg cell responses during homeostasis and Teff cell responses during colitis, as suggested by an increased overlap between the Teff/Treg TCR repertoires with colitis. Four of six Treg TCRs tested recognized mucosal-associated Helicobacter species in vitro and in vivo. By contrast, the marked expansion of luminal Bacteroides species seen during colitis did not trigger a commensurate Teff cell response. Unlike other Treg cell–inducing bacteria, Helicobacter species are known pathobionts and cause disease in immunodeficient mice. Thus, our study suggests a model in which mucosal bacteria elicit context-dependent Treg or Teff cell responses to facilitate intestinal tolerance or inflammation.

Original languageEnglish
Article numbereaal5068
JournalScience immunology
Volume2
Issue number13
DOIs
StatePublished - Jan 1 2017

Fingerprint Dive into the research topics of 'Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation'. Together they form a unique fingerprint.

  • Cite this

    Chai, J. N., Peng, Y., Rengarajan, S., Solomon, B. D., Ai, T. L., Shen, Z., Perry, J. S. A., Knoop, K. A., Tanoue, T., Narushima, S., Honda, K., Elson, C. O., Newberry, R. D., Stappenbeck, T. S., Kau, A. L., Peterson, D. A., Fox, J. G., & Hsieh, C. S. (2017). Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation. Science immunology, 2(13), [eaal5068]. https://doi.org/10.1126/sciimmunol.aal5068