Helicobacter pylori attaches to NeuAcα2,3Galβ1,4 glycoconjugates produced in the stomach of transgenic mice lacking parietal cells

Andrew J. Syder; Janaki L. Guruge; Qiutang Li; Yan Hu; Chandra M. Oleksiewicz; Robin G. Lorenz; Sherif M. Karam; Per G. Falk; Jeffrey I. Gordon

doi:10.1016/S1097-2765(00)80454-2

Helicobacter pylori attaches to NeuAcα2,3Galβ1,4 glycoconjugates produced in the stomach of transgenic mice lacking parietal cells

Andrew J. Syder, Janaki L. Guruge, Qiutang Li, Yan Hu, Chandra M. Oleksiewicz, Robin G. Lorenz, Sherif M. Karam, Per G. Falk, Jeffrey I. Gordon

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68 Scopus citations

Abstract

Helicobacter pylori infection of the human stomach is associated with altered acid secretion, loss of acid-producing parietal cells, and, in some hosts, adenocarcinoma. We have used a transgenic mouse model to study the effects of parietal cell ablation on H. pylori pathogenesis. Ablation results in amplification of the presumptive gastric epithelial stem cell and its immediate committed daughters. The amplified cells produce sialylated oncofetal carbohydrate antigens that function as receptors for H. pylori adhesins. Attachment results in enhanced cellular and humoral immune responses. NeuAcα2,3Galβ1,4 glycoconjugates may not only facilitate persistent H. pylori infection in a changing gastric ecosystem, but by promoting interactions with lineage progenitors and/or initiated cells contribute to tumorigenesis in patients with chronic atrophic gastritis.

Original language	English
Pages (from-to)	263-274
Number of pages	12
Journal	Molecular cell
Volume	3
Issue number	3
DOIs	https://doi.org/10.1016/S1097-2765(00)80454-2
State	Published - Mar 1999

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@article{2658fb52812a4df2bcce8229671b08a0,

title = "Helicobacter pylori attaches to NeuAcα2,3Galβ1,4 glycoconjugates produced in the stomach of transgenic mice lacking parietal cells",

abstract = "Helicobacter pylori infection of the human stomach is associated with altered acid secretion, loss of acid-producing parietal cells, and, in some hosts, adenocarcinoma. We have used a transgenic mouse model to study the effects of parietal cell ablation on H. pylori pathogenesis. Ablation results in amplification of the presumptive gastric epithelial stem cell and its immediate committed daughters. The amplified cells produce sialylated oncofetal carbohydrate antigens that function as receptors for H. pylori adhesins. Attachment results in enhanced cellular and humoral immune responses. NeuAcα2,3Galβ1,4 glycoconjugates may not only facilitate persistent H. pylori infection in a changing gastric ecosystem, but by promoting interactions with lineage progenitors and/or initiated cells contribute to tumorigenesis in patients with chronic atrophic gastritis.",

author = "Syder, {Andrew J.} and Guruge, {Janaki L.} and Qiutang Li and Yan Hu and Oleksiewicz, {Chandra M.} and Lorenz, {Robin G.} and Karam, {Sherif M.} and Falk, {Per G.} and Gordon, {Jeffrey I.}",

note = "Funding Information: We thank David O{\textquoteright}Donnell, Maria Karlsson, Glory Alexander, and M. Shane McNevin for their assistance. This work was supported by grants from the NIH (DK33487 to J. I. G.), the Swedish Cancer Society and the Swedish Foundation for Strategic Research (to P. G. F.), and the Kuwait Foundation for Advancement of Science (to S. K.). This study is dedicated to M. E. Gordon.",

year = "1999",

month = mar,

doi = "10.1016/S1097-2765(00)80454-2",

language = "English",

volume = "3",

pages = "263--274",

journal = "Molecular cell",

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TY - JOUR

T1 - Helicobacter pylori attaches to NeuAcα2,3Galβ1,4 glycoconjugates produced in the stomach of transgenic mice lacking parietal cells

AU - Syder, Andrew J.

AU - Guruge, Janaki L.

AU - Li, Qiutang

AU - Hu, Yan

AU - Oleksiewicz, Chandra M.

AU - Lorenz, Robin G.

AU - Karam, Sherif M.

AU - Falk, Per G.

AU - Gordon, Jeffrey I.

N1 - Funding Information: We thank David O’Donnell, Maria Karlsson, Glory Alexander, and M. Shane McNevin for their assistance. This work was supported by grants from the NIH (DK33487 to J. I. G.), the Swedish Cancer Society and the Swedish Foundation for Strategic Research (to P. G. F.), and the Kuwait Foundation for Advancement of Science (to S. K.). This study is dedicated to M. E. Gordon.

PY - 1999/3

Y1 - 1999/3

N2 - Helicobacter pylori infection of the human stomach is associated with altered acid secretion, loss of acid-producing parietal cells, and, in some hosts, adenocarcinoma. We have used a transgenic mouse model to study the effects of parietal cell ablation on H. pylori pathogenesis. Ablation results in amplification of the presumptive gastric epithelial stem cell and its immediate committed daughters. The amplified cells produce sialylated oncofetal carbohydrate antigens that function as receptors for H. pylori adhesins. Attachment results in enhanced cellular and humoral immune responses. NeuAcα2,3Galβ1,4 glycoconjugates may not only facilitate persistent H. pylori infection in a changing gastric ecosystem, but by promoting interactions with lineage progenitors and/or initiated cells contribute to tumorigenesis in patients with chronic atrophic gastritis.

AB - Helicobacter pylori infection of the human stomach is associated with altered acid secretion, loss of acid-producing parietal cells, and, in some hosts, adenocarcinoma. We have used a transgenic mouse model to study the effects of parietal cell ablation on H. pylori pathogenesis. Ablation results in amplification of the presumptive gastric epithelial stem cell and its immediate committed daughters. The amplified cells produce sialylated oncofetal carbohydrate antigens that function as receptors for H. pylori adhesins. Attachment results in enhanced cellular and humoral immune responses. NeuAcα2,3Galβ1,4 glycoconjugates may not only facilitate persistent H. pylori infection in a changing gastric ecosystem, but by promoting interactions with lineage progenitors and/or initiated cells contribute to tumorigenesis in patients with chronic atrophic gastritis.

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AN - SCOPUS:0033106225

SN - 1097-2765

VL - 3

SP - 263

EP - 274

JO - Molecular cell

JF - Molecular cell

IS - 3

ER -

Helicobacter pylori attaches to NeuAcα2,3Galβ1,4 glycoconjugates produced in the stomach of transgenic mice lacking parietal cells

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