Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis

Michelle A. Hurchla; Katherine N. Weilbaecher

doi:10.4161/onci.21060

Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis

Michelle A. Hurchla, Katherine N. Weilbaecher

Research output: Contribution to journal › Comment/debate

3 Scopus citations

Abstract

Paracrine Hedgehog (Hh) signaling, in which tumor-derived Hh ligands activate stromal cells, has been implicated in the development and progression of many cancers. Recent data suggest that Hh-targeted therapeutics exert direct effects on host cells, thus interrupting a "vicious cycle" to bone metastasis that involves osteoblasts, osteoclasts, and tumor cells.

Original language	English
Pages (from-to)	1411-1413
Number of pages	3
Journal	OncoImmunology
Volume	1
Issue number	8
DOIs	https://doi.org/10.4161/onci.21060
State	Published - 2012

Keywords

Bone metastasis
Hedgehog
Osteoclast
SMO antagonist
Sonic hedgehog
Tumor microenvironment

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10.4161/onci.21060

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title = "Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis",

abstract = "Paracrine Hedgehog (Hh) signaling, in which tumor-derived Hh ligands activate stromal cells, has been implicated in the development and progression of many cancers. Recent data suggest that Hh-targeted therapeutics exert direct effects on host cells, thus interrupting a {"}vicious cycle{"} to bone metastasis that involves osteoblasts, osteoclasts, and tumor cells.",

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AU - Hurchla, Michelle A.

AU - Weilbaecher, Katherine N.

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AB - Paracrine Hedgehog (Hh) signaling, in which tumor-derived Hh ligands activate stromal cells, has been implicated in the development and progression of many cancers. Recent data suggest that Hh-targeted therapeutics exert direct effects on host cells, thus interrupting a "vicious cycle" to bone metastasis that involves osteoblasts, osteoclasts, and tumor cells.

KW - Bone metastasis

KW - Hedgehog

KW - Osteoclast

KW - SMO antagonist

KW - Sonic hedgehog

KW - Tumor microenvironment

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DO - 10.4161/onci.21060

M3 - Comment/debate

C2 - 23243611

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VL - 1

SP - 1411

EP - 1413

JO - OncoImmunology

JF - OncoImmunology

IS - 8

ER -

Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis

Abstract

Keywords

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