3 Scopus citations

Abstract

Paracrine Hedgehog (Hh) signaling, in which tumor-derived Hh ligands activate stromal cells, has been implicated in the development and progression of many cancers. Recent data suggest that Hh-targeted therapeutics exert direct effects on host cells, thus interrupting a "vicious cycle" to bone metastasis that involves osteoblasts, osteoclasts, and tumor cells.

Original languageEnglish
Pages (from-to)1411-1413
Number of pages3
JournalOncoImmunology
Volume1
Issue number8
DOIs
StatePublished - 2012

Keywords

  • Bone metastasis
  • Hedgehog
  • Osteoclast
  • SMO antagonist
  • Sonic hedgehog
  • Tumor microenvironment

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