Hedgehog signaling pathway and lung cancer

Vamsidhar Velcheti, Ramaswamy Govindan

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Signaling pathways responsible for embryogenesis play a critical role in the maintenance of stem cells in adult life and cellular responses to injury. Dysfunction of the developmental signaling pathways during adult homeostasis leads to various events resulting in the development of neoplasia. We review the biology of the hedgehog signaling pathway and its potential role in the development of lung cancer.

Original languageEnglish
Pages (from-to)7-10
Number of pages4
JournalJournal of Thoracic Oncology
Volume2
Issue number1
DOIs
StatePublished - Jan 2007

Keywords

  • Hedgehog signaling
  • Lung cancer

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