Signaling pathways responsible for embryogenesis play a critical role in the maintenance of stem cells in adult life and cellular responses to injury. Dysfunction of the developmental signaling pathways during adult homeostasis leads to various events resulting in the development of neoplasia. We review the biology of the hedgehog signaling pathway and its potential role in the development of lung cancer.

Original languageEnglish
Pages (from-to)7-10
Number of pages4
JournalJournal of Thoracic Oncology
Issue number1
StatePublished - Jan 2007


  • Hedgehog signaling
  • Lung cancer


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