Hedgehog pathway inhibitors: Potential applications in breast cancer

Yee Hong Chia, Cynthia X. Ma

Research output: Contribution to journalArticle

1 Scopus citations


The Hedgehog (Hh) signaling pathway is a developmental pathway with important roles in embryogenesis, epithelial-mesenchymal transition, stem/progenitor cell renewal, and tissue regeneration and repair. Dysregulated Hh signaling is implicated in 25% of human cancers, including breast cancer. Mutations within elements of the Hh signaling pathway leading to ligand-independent activation do not appear to be widespread in breast cancer. However, overexpression of the Hh ligand and Hh target genes has been reported in breast cancer, suggesting a ligand-dependent mechanism for Hh pathway activation in breast carcinogenesis. Small molecule antagonists of the Hh pathway are under clinical development and may present novel therapeutic options for breast cancer.

Original languageEnglish
Pages (from-to)15-23
Number of pages9
JournalCurrent Breast Cancer Reports
Issue number1
StatePublished - Mar 1 2011


  • Breast cancer
  • Hedgehog

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