Hedgehog pathway inhibitors: Potential applications in breast cancer

Yee Hong Chia, Cynthia X. Ma

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The Hedgehog (Hh) signaling pathway is a developmental pathway with important roles in embryogenesis, epithelial-mesenchymal transition, stem/progenitor cell renewal, and tissue regeneration and repair. Dysregulated Hh signaling is implicated in 25% of human cancers, including breast cancer. Mutations within elements of the Hh signaling pathway leading to ligand-independent activation do not appear to be widespread in breast cancer. However, overexpression of the Hh ligand and Hh target genes has been reported in breast cancer, suggesting a ligand-dependent mechanism for Hh pathway activation in breast carcinogenesis. Small molecule antagonists of the Hh pathway are under clinical development and may present novel therapeutic options for breast cancer.

Original languageEnglish
Pages (from-to)15-23
Number of pages9
JournalCurrent Breast Cancer Reports
Volume3
Issue number1
DOIs
StatePublished - Mar 1 2011

Keywords

  • Breast cancer
  • Hedgehog

Fingerprint Dive into the research topics of 'Hedgehog pathway inhibitors: Potential applications in breast cancer'. Together they form a unique fingerprint.

  • Cite this