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Hedgehog-Gli pathway activation during kidney fibrosis
Steven L. Fabian
, Radostin R. Penchev
, Benoit St-Jacques
, Anjali N. Rao
, Petra Sipil
, Kip A. West
, Andrew P. McMahon
,
Benjamin D. Humphreys
Division of Nephrology
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
Department of Medicine
Center of Regenerative Medicine
DBBS - Computational and Systems Biology
DBBS - Developmental, Regenerative and Stem Cell Biology
Institute of Clinical and Translational Sciences (ICTS)
Research output
:
Contribution to journal
›
Article
›
peer-review
182
Scopus citations
Overview
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Keyphrases
Pathway Activation
100%
Kidney Fibrosis
100%
Hedgehog-Gli
100%
Hedgehog
100%
Gli1
80%
Gli2
60%
Indian Hedgehog
40%
Myofibroblast
40%
Renal Fibrosis
40%
IPI-926
40%
Hedgehog Signaling
40%
Adult Kidney
40%
Cell Proliferation
20%
Fibrosis
20%
Cell Cycle Progression
20%
Chronic Kidney Disease
20%
Sonic Hedgehog
20%
Paracrine
20%
Renal Tubular Epithelial Cells
20%
α-smooth muscle Actin (α-SMA)
20%
Reporter Mice
20%
Paracrine Signaling
20%
Cell Cycle Regulation
20%
Pericytes
20%
Interstitial Cells
20%
Tissue Patterning
20%
Hedgehog Antagonist
20%
Platelet-derived Growth Factor Receptor (PDGFR)
20%
Perivascular Fibroblasts
20%
Pericyte-like Cells
20%
Hedgehog Signaling Pathway
20%
Neuroscience
Hedgehog Signaling Pathway
100%
Myofibroblast
66%
In Vivo
33%
Cell Cycle Progression
33%
Cell Line
33%
Cell Proliferation
33%
Face
33%
Epithelial Cells
33%
Paracrine Signalling
33%
Platelet-Derived Growth Factor Receptor
33%
Smooth Muscle Actin
33%
Sonic Hedgehog
33%
Interstitial Cell
33%
Fibroblast
33%
Biochemistry, Genetics and Molecular Biology
Hedgehog
100%
Hedgehog Signaling Pathway
30%
Pericyte
20%
Myofibroblast
20%
Cell Cycle Progression
10%
Cell Proliferation
10%
Sonic Hedgehog
10%
Actin
10%
Platelet-Derived Growth Factor Receptor
10%
Paracrine Signalling
10%
Fibroblast
10%
Pharmacology, Toxicology and Pharmaceutical Science
Kidney Fibrosis
100%
Hedgehog
100%
Fibrosis
7%
Chronic Kidney Failure
7%
Smooth Muscle Actin
7%
Sonic Hedgehog Protein
7%
Platelet Derived Growth Factor Receptor
7%