TY - JOUR
T1 - Heated intraperitoneal chemotherapy in the management of advanced ovarian cancer
AU - Jewell, Andrea
AU - McMahon, Megan
AU - Khabele, Dineo
N1 - Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Heated intraperitoneal chemotherapy (HIPEC) has several potential benefits. Higher doses of chemotherapy can be used with HIPEC because the plasma-peritoneal barrier results in little absorption into the blood stream. HIPEC offers higher peritoneal penetration in comparison to an intravenous (IV) regimen and does not have the traditional normothermic intraperitoneal (IP) regimen limitation of post-operative adhesions. Hyperthermia itself has cytotoxic effects and can potentiate antineoplastic effects of chemotherapy in part by increasing the depth of tumor penetration by up to 3 mm. For the treatment of ovarian cancer, HIPEC has been evaluated in the recurrent setting with secondary cytoreduction. Recent studies, including a prospective trial, have evaluated its role in primary management of ovarian cancer. This review summarizes previous and ongoing studies regarding the use of HIPEC in the management of ovarian cancer.
AB - Heated intraperitoneal chemotherapy (HIPEC) has several potential benefits. Higher doses of chemotherapy can be used with HIPEC because the plasma-peritoneal barrier results in little absorption into the blood stream. HIPEC offers higher peritoneal penetration in comparison to an intravenous (IV) regimen and does not have the traditional normothermic intraperitoneal (IP) regimen limitation of post-operative adhesions. Hyperthermia itself has cytotoxic effects and can potentiate antineoplastic effects of chemotherapy in part by increasing the depth of tumor penetration by up to 3 mm. For the treatment of ovarian cancer, HIPEC has been evaluated in the recurrent setting with secondary cytoreduction. Recent studies, including a prospective trial, have evaluated its role in primary management of ovarian cancer. This review summarizes previous and ongoing studies regarding the use of HIPEC in the management of ovarian cancer.
KW - Cytoreductive surgery
KW - Heated intraperitoneal chemotherapy (hipec)
KW - Interval cytoreduction
KW - Intraperitoneal chemotherapy (ip)
KW - Ovarian cancer
KW - Secondary cytoreduction
UR - http://www.scopus.com/inward/record.url?scp=85052995154&partnerID=8YFLogxK
U2 - 10.3390/cancers10090296
DO - 10.3390/cancers10090296
M3 - Review article
AN - SCOPUS:85052995154
SN - 2072-6694
VL - 10
JO - Cancers
JF - Cancers
IS - 9
M1 - 296
ER -