heat stress reduces glutamate toxicity in cultued neurons without HSP70 expression

B. Joy Snider, Dennis W. Choi

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Consistent with known cytoprotective effects, mild heat stress reduced the vulnerability of cultured cortical neurons to glutamate-induced cell death. However, this neuroprotective effect occurred without expression of the inducible heat stress protein, hsp70, as detected by immunocytochemistry, immunoblotting, or metabolic labeling. Present data suggest that the anti-excitotoxic effect of mild heat stress is mediated outside of the traditional hsp70 mechanism.

Original languageEnglish
Pages (from-to)273-276
Number of pages4
JournalBrain Research
Volume729
Issue number2
DOIs
StatePublished - Aug 12 1996

Keywords

  • Cultured neuron
  • Excitotoxicity
  • Gene expression
  • Heat shock protein
  • Heat stress
  • Neuroprotection

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