Heart rate variability biomarkers of leucine-rich repeat kinase 2-associated Parkinson's disease

Claudia Carricarte Naranjo, Connie Marras, Naomi P. Visanji, David J. Cornforth, Lazaro Sanchez-Rodriguez, Birgitt Schule, Samuel M. Goldman, Mario Estevez, Phyllis K. Stein, Anthony E. Lang, Andres Machado, Herbert F. Jelinek

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common known cause of both familial and sporadic Parkinson's disease (PD). On a single patient basis, LRRK2-associated PD (LRRK2-PD) and idiopathic PD (iPD) are indistinguishable. Recent evidence suggests that LRRK2-PD may be related to greater vagal activity. This study aimed to explore the potential of standard and novel heart rate variability (HRV) measures to distinguish LRRK2-PD from iPD patients. Support vector machine classifiers, based on HRV features, were used to discriminate between PD types. The combination of two classifiers reached 79% sensitivity and 86% specificity. Cardiac autonomic biomarkers may be useful to accurately distinguish individuals with LRRK2-PD from iPD.

Original languageEnglish
Title of host publication2020 11th Conference of the European Study Group on Cardiovascular Oscillations
Subtitle of host publicationComputation and Modelling in Physiology: New Challenges and Opportunities, ESGCO 2020
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781728157511
DOIs
StatePublished - Jul 2020
Event11th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO 2020 - Virtual, Online, Italy
Duration: Jul 15 2020 → …

Publication series

Name2020 11th Conference of the European Study Group on Cardiovascular Oscillations: Computation and Modelling in Physiology: New Challenges and Opportunities, ESGCO 2020

Conference

Conference11th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO 2020
CountryItaly
CityVirtual, Online
Period07/15/20 → …

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