TY - JOUR
T1 - Heart rate variability as a biomarker of functional outcomes in persons with acquired brain injury
T2 - Systematic review and meta-analysis
AU - Lee, Yejin
AU - Walsh, Ryan J.
AU - Fong, Mandy W.M.
AU - Sykora, Marek
AU - Doering, Michelle M.
AU - Wong, Alex W.K.
N1 - Funding Information:
The US Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)/National Center for Medical Rehabilitation Research (NCMRR) (K01HD095388), the NICHD and National Institute of Neurological Disorders and Stroke (NINDS)-funded Center for Smart Use of Technologies to Assess Real-world Outcomes (C-STAR) (P2CHD101899), and the American Occupational Therapy Foundation (AOTFIRG20Wong) supported a portion of Dr. Wong's effort for developing this manuscript.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/12
Y1 - 2021/12
N2 - This review aimed to quantify correlations between heart rate variability (HRV) and functional outcomes after acquired brain injury (ABI). We conducted a literature search from inception to January 2020 via electronic databases, using search terms with HRV, ABI, and functional outcomes. Meta-analyses included 16 studies with 906 persons with ABI. Results demonstrated significant associations: Low frequency (LF) (r = −0.28) and SDNN (r = −0.33) with neurological function; LF (r = −0.33), High frequency (HF) (r = −0.22), SDNN (r = −0.22), and RMSSD (r = −0.23) with emotional function; and LF (r = 0.34), HF (r = 0.41 to 0.43), SDNN (r = 0.43 to 0.51), and RMSSD (r = 0.46) with behavioral function. Results indicate that higher HRV is related to better neurological, emotional, and behavioral functions after ABI. In addition, persons with stroke showed lower HF (SMD = −0.50) and SDNN (SMD = −0.75) than healthy controls. The findings support the use of HRV as a biomarker to facilitate precise monitoring of post-ABI functions.
AB - This review aimed to quantify correlations between heart rate variability (HRV) and functional outcomes after acquired brain injury (ABI). We conducted a literature search from inception to January 2020 via electronic databases, using search terms with HRV, ABI, and functional outcomes. Meta-analyses included 16 studies with 906 persons with ABI. Results demonstrated significant associations: Low frequency (LF) (r = −0.28) and SDNN (r = −0.33) with neurological function; LF (r = −0.33), High frequency (HF) (r = −0.22), SDNN (r = −0.22), and RMSSD (r = −0.23) with emotional function; and LF (r = 0.34), HF (r = 0.41 to 0.43), SDNN (r = 0.43 to 0.51), and RMSSD (r = 0.46) with behavioral function. Results indicate that higher HRV is related to better neurological, emotional, and behavioral functions after ABI. In addition, persons with stroke showed lower HF (SMD = −0.50) and SDNN (SMD = −0.75) than healthy controls. The findings support the use of HRV as a biomarker to facilitate precise monitoring of post-ABI functions.
KW - Biomarker
KW - Brain injuries
KW - Functional outcomes
KW - Heart rate variability
KW - Meta-analysis
KW - Outcome assessment (health care)
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=85116593483&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2021.10.004
DO - 10.1016/j.neubiorev.2021.10.004
M3 - Review article
C2 - 34626686
AN - SCOPUS:85116593483
SN - 0149-7634
VL - 131
SP - 737
EP - 754
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -