TY - JOUR
T1 - Heart Failure With Recovered Left Ventricular Ejection Fraction
T2 - JACC Scientific Expert Panel
AU - Wilcox, Jane E.
AU - Fang, James C.
AU - Margulies, Kenneth B.
AU - Mann, Douglas L.
N1 - Publisher Copyright:
© 2020 American College of Cardiology Foundation
PY - 2020/8/11
Y1 - 2020/8/11
N2 - Reverse left ventricular (LV) remodeling and recovery of LV function are associated with improved clinical outcomes in patients with heart failure with reduced ejection fraction. A growing body of evidence suggests that even among patients who experience a complete normalization of LV ejection fraction, a significant proportion will develop recurrent LV dysfunction accompanied by recurrent heart failure events. This has led to intense interest in understanding how to manage patients with heart failure with recovered ejection fraction (HFrecEF). Because of the lack of a standard definition for HFrecEF, and the paucity of clinical data with respect to the natural history of HFrecEF patients, there are no current guidelines on how these patients should be followed up and managed. Accordingly, this JACC Scientific Expert Panel reviews the biology of reverse LV remodeling and the clinical course of patients with HFrecEF, as well as provides guidelines for defining, diagnosing, and managing patients with HFrecEF.
AB - Reverse left ventricular (LV) remodeling and recovery of LV function are associated with improved clinical outcomes in patients with heart failure with reduced ejection fraction. A growing body of evidence suggests that even among patients who experience a complete normalization of LV ejection fraction, a significant proportion will develop recurrent LV dysfunction accompanied by recurrent heart failure events. This has led to intense interest in understanding how to manage patients with heart failure with recovered ejection fraction (HFrecEF). Because of the lack of a standard definition for HFrecEF, and the paucity of clinical data with respect to the natural history of HFrecEF patients, there are no current guidelines on how these patients should be followed up and managed. Accordingly, this JACC Scientific Expert Panel reviews the biology of reverse LV remodeling and the clinical course of patients with HFrecEF, as well as provides guidelines for defining, diagnosing, and managing patients with HFrecEF.
KW - heart failure with recovered ejection fraction
KW - myocardial recovery
UR - http://www.scopus.com/inward/record.url?scp=85088842408&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2020.05.075
DO - 10.1016/j.jacc.2020.05.075
M3 - Review article
C2 - 32762907
AN - SCOPUS:85088842408
SN - 0735-1097
VL - 76
SP - 719
EP - 734
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 6
ER -