TY - JOUR
T1 - Heart failure with preserved ejection fraction
T2 - Similarities and differences between women and men
AU - the American College of Cardiology Committee on Cardiovascular Disease in Women
AU - Pepine, Carl J.
AU - Merz, C. Noel Bairey
AU - El Hajj, Stephanie
AU - Ferdinand, Keith C.
AU - Hamilton, Michele A.
AU - Lindley, Kathryn J.
AU - Nelson, Michael D.
AU - Quesada, Odayme
AU - Wenger, Nanette K.
AU - Fleg, Jerome L.
N1 - Funding Information:
We thank Kyler Conn and Nancy Lanni for editorial assistance.
Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - The syndrome of heart failure (HF) with preserved ejection fraction (HFpEF) is now recognized to account for up to half of HF cases and is the dominant form of HF in older adults, especially women. Multiple factors conspire in this predilection of HFpEF for older women. This review will discuss the epidemiology, pathophysiology, prognosis, and treatment of HFpEF with emphasis on the similarities and differences in cardiovascular aging changes, and the differential impact of comorbidities in women versus men. Responses to pharmacologic and lifestyle interventions are also reviewed. We conclude by suggesting future directions for both prevention and treatment of this common and highly morbid cardiovascular disorder.
AB - The syndrome of heart failure (HF) with preserved ejection fraction (HFpEF) is now recognized to account for up to half of HF cases and is the dominant form of HF in older adults, especially women. Multiple factors conspire in this predilection of HFpEF for older women. This review will discuss the epidemiology, pathophysiology, prognosis, and treatment of HFpEF with emphasis on the similarities and differences in cardiovascular aging changes, and the differential impact of comorbidities in women versus men. Responses to pharmacologic and lifestyle interventions are also reviewed. We conclude by suggesting future directions for both prevention and treatment of this common and highly morbid cardiovascular disorder.
KW - Heart failure with preserved ejection fraction
KW - Older women
KW - Sex differences
UR - http://www.scopus.com/inward/record.url?scp=85078036271&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2020.01.003
DO - 10.1016/j.ijcard.2020.01.003
M3 - Article
C2 - 31959407
AN - SCOPUS:85078036271
SN - 0167-5273
VL - 304
SP - 101
EP - 108
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -