Heart Failure Subtypes and Cardiomyopathies in Women

Ersilia M. Defilippis, Anna Beale, Trejeeve Martin, Anubha Agarwal, Uri Elkayam, Carolyn S.P. Lam, Eileen Hsich

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Heart failure affects over 2.6 million women and 3.4 million men in the United States with known sex differences in epidemiology, management, response to treatment, and outcomes across a wide spectrum of cardiomyopathies that include peripartum cardiomyopathy, hypertrophic cardiomyopathy, stress cardiomyopathy, cardiac amyloidosis, and sarcoidosis. Some of these sex-specific considerations are driven by the cellular effects of sex hormones on the renin-angiotensin-aldosterone system, endothelial response to injury, vascular aging, and left ventricular remodeling. Other sex differences are perpetuated by implicit bias leading to undertreatment and underrepresentation in clinical trials. The goal of this narrative review is to comprehensively examine the existing literature over the last decade regarding sex differences in various heart failure syndromes from pathophysiological insights to clinical practice.

Original languageEnglish
Pages (from-to)436-454
Number of pages19
JournalCirculation research
Issue number4
StatePublished - Feb 18 2022


  • cardiomyopathies
  • estrogens
  • heart failure
  • peripartum
  • women


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