TY - JOUR
T1 - Heart Failure in the Era of Precision Medicine
T2 - A Scientific Statement from the American Heart Association
AU - Cresci, Sharon
AU - Pereira, Naveen L.
AU - Ahmad, Ferhaan
AU - Byku, Mirnela
AU - De Las Fuentes, Lisa
AU - Lanfear, David E.
AU - Reilly, Carolyn M.
AU - Owens, Anjali T.
AU - Wolf, Matthew J.
N1 - Funding Information:
NIH (research grant to support investigations of cardiac hypertrophy)†
Funding Information:
PCORI†; NIH NHLBI (K23 HL105896)†; AHA (grant SFRN)†
Publisher Copyright:
© 2019 Lippincott Williams and Wilkins. All rights reserved.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - One of 5 people will develop heart failure over his or her lifetime. Early diagnosis and better understanding of the pathophysiology of this disease are critical to optimal treatment. The "omics" - genomics, pharmacogenomics, epigenomics, proteomics, metabolomics, and microbiomics - of heart failure represent rapidly expanding fields of science that have, to date, not been integrated into a single body of work. The goals of this statement are to provide a comprehensive overview of the current state of these omics as they relate to the development and progression of heart failure and to consider the current and potential future applications of these data for precision medicine with respect to prevention, diagnosis, and therapy.
AB - One of 5 people will develop heart failure over his or her lifetime. Early diagnosis and better understanding of the pathophysiology of this disease are critical to optimal treatment. The "omics" - genomics, pharmacogenomics, epigenomics, proteomics, metabolomics, and microbiomics - of heart failure represent rapidly expanding fields of science that have, to date, not been integrated into a single body of work. The goals of this statement are to provide a comprehensive overview of the current state of these omics as they relate to the development and progression of heart failure and to consider the current and potential future applications of these data for precision medicine with respect to prevention, diagnosis, and therapy.
KW - AHA Scientific Statements
KW - early diagnosis
KW - heart failure
KW - precision medicine
KW - preventive medicine
UR - http://www.scopus.com/inward/record.url?scp=85073307298&partnerID=8YFLogxK
U2 - 10.1161/HCG.0000000000000058
DO - 10.1161/HCG.0000000000000058
M3 - Review article
C2 - 31510778
AN - SCOPUS:85073307298
SN - 2574-8300
VL - 12
SP - 458
EP - 485
JO - Circulation: Genomic and Precision Medicine
JF - Circulation: Genomic and Precision Medicine
IS - 10
M1 - e000058
ER -