Heart block and acute kidney injury due to hyperparathyroidism-induced hypercalcemic crisis

Taylor C. Brown, James M. Healy, Mary J. McDonald, Joni H. Hansson, Courtney E. Quinn

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


We describe a patient who presented with multi-system organ failure due to extreme hy-percalcemia (serum calcium 19.8 mg/dL), resulting from primary hyperparathyroidism. He was found to have a 4.8 cm solitary atypical parathyroid adenoma. His course was complicated by complete heart block, acute kidney injury, and significant neurocognitive disturbances. Relevant literature was reviewed and discussed. Hyperparathyroidism-induced hypercalcemic crisis (HIHC†) is a rare presentation of primary hyperparathyroidism and only a small minority of these patients develop significant cardiac and renal complications. In cases of HIHC, a multidisciplinary effort can facilitate rapid treatment of life-threatening hy-percalcemia and definitive treatment by surgical resection. As such, temporary transvenous cardiac pacing and renal replacement therapy can provide a life-saving bridge to definitive parathyroidectomy in cases of HIHC.

Original languageEnglish
Pages (from-to)563-567
Number of pages5
JournalYale Journal of Biology and Medicine
Issue number4
StatePublished - Dec 12 2014


  • Acute kidney injury
  • Heart block
  • Hypercalcemic crisis
  • Hyperparathyroidism


Dive into the research topics of 'Heart block and acute kidney injury due to hyperparathyroidism-induced hypercalcemic crisis'. Together they form a unique fingerprint.

Cite this