Healthy lifestyle and decreasing risk of heart failure in women: The women's health initiative observational study

Golareh Agha, Eric B. Loucks, Lesley F. Tinker, Molly E. Waring, Dominique S. Michaud, Randi E. Foraker, Wenjun Li, Lisa W. Martin, Philip Greenland, Joann E. Manson, Charles B. Eaton

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Background The impact of a healthy lifestyle on risk of heart failure (HF) is not well known. Objectives The objectives of this study were to evaluate the effect of a combination of lifestyle factors on incident HF and to further investigate whether weighting each lifestyle factor has additional impact

Methods Participants were 84,537 post-menopausal women from the WHI (Women's Health Initiative) observational study, free of self-reported HF at baseline. A healthy lifestyle score (HL score) was created wherein women received 1 point for each healthy criterion met: high-scoring Alternative Healthy Eating Index, physically active, healthy body mass index, and currently not smoking. A weighted score (wHL score) was also created in which each lifestyle factor was weighted according to its independent magnitude of effect on HF. The incidence of hospitalized HF was determined by trained adjudicators using standardized methodology-absp. Results There were 1,826 HF cases over a mean follow-up of 11 years. HL score was strongly associated with risk of HF (multivariable-Adjusted hazard ratio [HR] [95% confidence interval (CI)] 0.49 [95% CI: 0.38 to 0.62], 0.36 [95% CI: 0.28 to 0.46], 0.24 [95% CI: 0.19 to 0.31], and 0.23 [95% CI: 0.17 to 0.30] for HL score of 1, 2, 3, and 4 vs. 0, respectively). The HL score and wHL score were similarly associated with HF risk (HR: 0.46 [95% CI: 0.41 to 0.52] for HL score; HR: 0.48 [95% CI: 0.42 to 0.55] for wHL score, comparing the highest tertile to the lowest). The HL score was also strongly associated with HF risk among women without antecedent coronary heart disease, diabetes, or hypertension-absp. Conclusions An increasingly healthy lifestyle was associated with decreasing HF risk among post-menopausal women, even in the absence of antecedent coronary heart disease, hypertension, and diabetes. Weighting the lifestyle factors had minimal impact.

Original languageEnglish
Pages (from-to)1777-1785
Number of pages9
JournalJournal of the American College of Cardiology
Volume64
Issue number17
DOIs
StatePublished - Oct 28 2014

Keywords

  • cardiovascular diseases
  • heart failure
  • lifestyle
  • primary prevention
  • risk factors

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