TY - JOUR
T1 - Health-Related Quality of Life 'Well-Being' in HIV Distal Neuropathic Pain is More Strongly Associated with Depression Severity than with Pain Intensity
AU - Keltner, John R.
AU - Vaida, Florin
AU - Ellis, Ronald J.
AU - Moeller-Bertram, Tobias
AU - Fitzsimmons, Chelsea
AU - Duarte, Nichole A.
AU - Robinson-Papp, Jessica
AU - Dworkin, Robert H.
AU - Clifford, David B.
AU - McArthur, Justin C.
AU - Simpson, David M.
AU - Collier, Ann C.
AU - Marra, Christina M.
AU - Atkinson, J. Hampton
AU - Grant, Igor
N1 - Funding Information:
This research was supported by awards N01 MH22005 from the National Institutes of Health .
PY - 2012/7
Y1 - 2012/7
N2 - Background: Despite modern antiretroviral treatment, HIV-associated distal neuropathic pain (DNP) remains one of the most prevalent and debilitating complications of HIV disease. Neuropathic pain is often accompanied by depressed mood, and both pain and depression have been associated with decreased health-related quality of life (HRQOL) well-being. The relative contribution of depression and pain to worse life quality has not been addressed, however, even though a better understanding might sharpen intervention strategies. Methods: We used the Medical Outcomes Study HIV (MOS-HIV) Health Survey and the Beck Depression Inventory-II and linear regression models to investigate HRQOL well-being in HIV-infected patients with DNP (n = 397) participating in an observational cohort study at six US sites (CNS HIV Antiretroviral Treatment Effects Research Study, CHARTER). Results: For this sample of patients with HIV DNP, severity of depressed mood was more highly correlated with HRQOL well-being than was pain intensity. Conclusions: These results suggest that interventions to improve HRQOL well-being in individuals with HIV-associated DNP may need to address not only pain intensity but mood state as well.
AB - Background: Despite modern antiretroviral treatment, HIV-associated distal neuropathic pain (DNP) remains one of the most prevalent and debilitating complications of HIV disease. Neuropathic pain is often accompanied by depressed mood, and both pain and depression have been associated with decreased health-related quality of life (HRQOL) well-being. The relative contribution of depression and pain to worse life quality has not been addressed, however, even though a better understanding might sharpen intervention strategies. Methods: We used the Medical Outcomes Study HIV (MOS-HIV) Health Survey and the Beck Depression Inventory-II and linear regression models to investigate HRQOL well-being in HIV-infected patients with DNP (n = 397) participating in an observational cohort study at six US sites (CNS HIV Antiretroviral Treatment Effects Research Study, CHARTER). Results: For this sample of patients with HIV DNP, severity of depressed mood was more highly correlated with HRQOL well-being than was pain intensity. Conclusions: These results suggest that interventions to improve HRQOL well-being in individuals with HIV-associated DNP may need to address not only pain intensity but mood state as well.
UR - http://www.scopus.com/inward/record.url?scp=84868004953&partnerID=8YFLogxK
U2 - 10.1016/j.psym.2012.05.002
DO - 10.1016/j.psym.2012.05.002
M3 - Article
C2 - 22748751
AN - SCOPUS:84868004953
SN - 0033-3182
VL - 53
SP - 380
EP - 386
JO - Psychosomatics
JF - Psychosomatics
IS - 4
ER -