Health-related quality of life before and after pediatric epilepsy surgery: The influence of seizure outcome on changes in physical functioning and social functioning

Jeffrey B. Titus; Amy Lee; Aimen Kasasbeh; Liu Lin Thio; Jennifer Stephenson; Karen Steger-May; David D. Limbrick; Matthew D. Smyth

doi:10.1016/j.yebeh.2013.03.003

Health-related quality of life before and after pediatric epilepsy surgery: The influence of seizure outcome on changes in physical functioning and social functioning

Jeffrey B. Titus, Amy Lee, Aimen Kasasbeh, Liu Lin Thio, Jennifer Stephenson, Karen Steger-May, David D. Limbrick, Matthew D. Smyth

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Health-related quality of life (HRQOL) is an important outcome in pediatric epilepsy surgery, but there are few studies that utilize presurgical ratings to assess the effect of surgery on HRQOL. We collected parental ratings on the Quality of Life in Childhood Epilepsy (QOLCE) questionnaire for 28 children who participated in neuropsychological assessment before and after epilepsy surgery. Our results revealed significant improvements in overall HRQOL after surgery, especially in physical and social activities. These changes were apparent despite generally unchanged intellectual and psychological functioning. Children with better seizure outcome had more improvement in HRQOL; however, improvements were not statistically different among children with Engel class I, II, and III outcomes. Our results suggest that children can experience significant improvements in HRQOL following epilepsy surgery even when neuropsychological functioning remains unchanged. Moreover, improvements in HRQOL appear evident in children who experience any worthwhile improvement in seizure control (Engel class III or better).

Original language	English
Pages (from-to)	477-483
Number of pages	7
Journal	Epilepsy and Behavior
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/j.yebeh.2013.03.003
State	Published - Jun 2013

Keywords

Behavior
Cognition
Epilepsy
Outcome
Pediatric
Quality of life
Seizures
Surgery

Access to Document

10.1016/j.yebeh.2013.03.003

Cite this

Titus, J. B., Lee, A., Kasasbeh, A., Thio, L. L., Stephenson, J., Steger-May, K., Limbrick, D. D., & Smyth, M. D. (2013). Health-related quality of life before and after pediatric epilepsy surgery: The influence of seizure outcome on changes in physical functioning and social functioning. Epilepsy and Behavior, 27(3), 477-483. https://doi.org/10.1016/j.yebeh.2013.03.003

@article{854be37cab8c43c1b7228b1b9d4d8526,

title = "Health-related quality of life before and after pediatric epilepsy surgery: The influence of seizure outcome on changes in physical functioning and social functioning",

abstract = "Health-related quality of life (HRQOL) is an important outcome in pediatric epilepsy surgery, but there are few studies that utilize presurgical ratings to assess the effect of surgery on HRQOL. We collected parental ratings on the Quality of Life in Childhood Epilepsy (QOLCE) questionnaire for 28 children who participated in neuropsychological assessment before and after epilepsy surgery. Our results revealed significant improvements in overall HRQOL after surgery, especially in physical and social activities. These changes were apparent despite generally unchanged intellectual and psychological functioning. Children with better seizure outcome had more improvement in HRQOL; however, improvements were not statistically different among children with Engel class I, II, and III outcomes. Our results suggest that children can experience significant improvements in HRQOL following epilepsy surgery even when neuropsychological functioning remains unchanged. Moreover, improvements in HRQOL appear evident in children who experience any worthwhile improvement in seizure control (Engel class III or better).",

keywords = "Behavior, Cognition, Epilepsy, Outcome, Pediatric, Quality of life, Seizures, Surgery",

author = "Titus, {Jeffrey B.} and Amy Lee and Aimen Kasasbeh and Thio, {Liu Lin} and Jennifer Stephenson and Karen Steger-May and Limbrick, {David D.} and Smyth, {Matthew D.}",

year = "2013",

month = jun,

doi = "10.1016/j.yebeh.2013.03.003",

language = "English",

volume = "27",

pages = "477--483",

journal = "Epilepsy and Behavior",

issn = "1525-5050",

number = "3",

}

TY - JOUR

T1 - Health-related quality of life before and after pediatric epilepsy surgery

T2 - The influence of seizure outcome on changes in physical functioning and social functioning

AU - Titus, Jeffrey B.

AU - Lee, Amy

AU - Kasasbeh, Aimen

AU - Thio, Liu Lin

AU - Stephenson, Jennifer

AU - Steger-May, Karen

AU - Limbrick, David D.

AU - Smyth, Matthew D.

PY - 2013/6

Y1 - 2013/6

N2 - Health-related quality of life (HRQOL) is an important outcome in pediatric epilepsy surgery, but there are few studies that utilize presurgical ratings to assess the effect of surgery on HRQOL. We collected parental ratings on the Quality of Life in Childhood Epilepsy (QOLCE) questionnaire for 28 children who participated in neuropsychological assessment before and after epilepsy surgery. Our results revealed significant improvements in overall HRQOL after surgery, especially in physical and social activities. These changes were apparent despite generally unchanged intellectual and psychological functioning. Children with better seizure outcome had more improvement in HRQOL; however, improvements were not statistically different among children with Engel class I, II, and III outcomes. Our results suggest that children can experience significant improvements in HRQOL following epilepsy surgery even when neuropsychological functioning remains unchanged. Moreover, improvements in HRQOL appear evident in children who experience any worthwhile improvement in seizure control (Engel class III or better).

AB - Health-related quality of life (HRQOL) is an important outcome in pediatric epilepsy surgery, but there are few studies that utilize presurgical ratings to assess the effect of surgery on HRQOL. We collected parental ratings on the Quality of Life in Childhood Epilepsy (QOLCE) questionnaire for 28 children who participated in neuropsychological assessment before and after epilepsy surgery. Our results revealed significant improvements in overall HRQOL after surgery, especially in physical and social activities. These changes were apparent despite generally unchanged intellectual and psychological functioning. Children with better seizure outcome had more improvement in HRQOL; however, improvements were not statistically different among children with Engel class I, II, and III outcomes. Our results suggest that children can experience significant improvements in HRQOL following epilepsy surgery even when neuropsychological functioning remains unchanged. Moreover, improvements in HRQOL appear evident in children who experience any worthwhile improvement in seizure control (Engel class III or better).

KW - Behavior

KW - Cognition

KW - Epilepsy

KW - Outcome

KW - Pediatric

KW - Quality of life

KW - Seizures

KW - Surgery

UR - http://www.scopus.com/inward/record.url?scp=84877056985&partnerID=8YFLogxK

U2 - 10.1016/j.yebeh.2013.03.003

DO - 10.1016/j.yebeh.2013.03.003

M3 - Article

C2 - 23631952

AN - SCOPUS:84877056985

SN - 1525-5050

VL - 27

SP - 477

EP - 483

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

IS - 3

ER -

Health-related quality of life before and after pediatric epilepsy surgery: The influence of seizure outcome on changes in physical functioning and social functioning

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this