TY - JOUR
T1 - Headache outcomes following treatment of unruptured intracranial aneurysms
T2 - A prospective analysis
AU - Schwedt, Todd J.
AU - Gereau, Robert W.
AU - Frey, Karen
AU - Kharasch, Evan D.
N1 - Funding Information:
These studies were supported by NIH grants KL2RR024994 and UL1RR024992 to TJS, NIH grant K24DA00417 to EDK, and NIH grant R01NS048602 to RWG.
PY - 2011/7
Y1 - 2011/7
N2 - Objective: To analyze headache patterns prior to and following treatment of unruptured intracranial aneurysms and identify factors associated with different headache outcomes.Methods: A prospective observational study of patients being treated for unruptured intracranial aneurysms. Headache patterns were established prior to aneurysm treatment and for 6 months following treatment. Factors associated with different headache outcomes were investigated.Results: In all patients (n = 44), 90-day headache frequency decreased from an average of 31 days prior to aneurysm treatment to 17 days following treatment (p < 0.001). In patients with active pretreatment headaches (n = 28), 90-day headache frequency decreased from 49 days to 26 days (p = 0.002). Headache frequency was reduced in 68% of patients, while 9% of patients had new or worsened headaches following aneurysm treatment. Pretreatment migraine, more severe pretreatment headaches, higher pretreatment trait anxiety, and stent-assisted aneurysm coiling were associated with a lack of headache improvement.Conclusions: The majority of patients with headaches at the time of aneurysm treatment had reductions in headache frequency during the 6 months following treatment. Potential risk factors for poor headache outcomes were identified but need to be studied further.
AB - Objective: To analyze headache patterns prior to and following treatment of unruptured intracranial aneurysms and identify factors associated with different headache outcomes.Methods: A prospective observational study of patients being treated for unruptured intracranial aneurysms. Headache patterns were established prior to aneurysm treatment and for 6 months following treatment. Factors associated with different headache outcomes were investigated.Results: In all patients (n = 44), 90-day headache frequency decreased from an average of 31 days prior to aneurysm treatment to 17 days following treatment (p < 0.001). In patients with active pretreatment headaches (n = 28), 90-day headache frequency decreased from 49 days to 26 days (p = 0.002). Headache frequency was reduced in 68% of patients, while 9% of patients had new or worsened headaches following aneurysm treatment. Pretreatment migraine, more severe pretreatment headaches, higher pretreatment trait anxiety, and stent-assisted aneurysm coiling were associated with a lack of headache improvement.Conclusions: The majority of patients with headaches at the time of aneurysm treatment had reductions in headache frequency during the 6 months following treatment. Potential risk factors for poor headache outcomes were identified but need to be studied further.
KW - Aneurysm clip
KW - aneurysm coil
KW - central sensitization
KW - headache
KW - intracranial aneurysm
UR - http://www.scopus.com/inward/record.url?scp=79960716312&partnerID=8YFLogxK
U2 - 10.1177/0333102411398155
DO - 10.1177/0333102411398155
M3 - Article
C2 - 21398420
AN - SCOPUS:79960716312
VL - 31
SP - 1082
EP - 1089
JO - Cephalalgia
JF - Cephalalgia
SN - 0333-1024
IS - 10
ER -