@article{c53de7a50cbf4c7c96a7767f94110901,
title = "Head tremor and pain in cervical dystonia",
abstract = "Background: Although head tremor (HT) and pain are prevalent in cervical dystonia (CD), their joint relationship to phenotypic features of focal dystonia remains unclear. Objectives: We examined how severity of HT and pain are associated with age of CD onset and duration, and whether HT subtypes (“jerky” or “regular”) exhibit distinct relationships between severity of HT and pain. Methods: The severity of HT and pain were assessed with the Toronto Western Spasmodic Torticollis Rating Scale in retrospective review of 188 CD patients recruited through the Dystonia Coalition. Results: HT severity was associated with longer CD duration (p < 0.0005), whereas pain severity was associated with younger age at onset (p = 0.043). HT severity and pain severity were not correlated for jerky HT (p = 0.996), but positively correlated for regular HT (p = 0.01). Conclusions: The distinct associations of HT and pain with age at onset, disease duration, and HT subtype further characterize the heterogeneity of CD{\textquoteright}s clinical presentation and suggest similarly heterogeneous underlying mechanisms.",
keywords = "Cervical dystonia, Dystonic tremor, Head tremor, Pain",
author = "Vu, {Jeanne P.} and Lee, {Ha Yeon} and Qiyu Chen and Elizabeth Cisneros and Barbano, {Richard L.} and Goetz, {Christopher G.} and Joseph Jankovic and Jinnah, {Hyder A.} and Perlmutter, {Joel S.} and Berman, {Brian D.} and Appelbaum, {Mark I.} and Stebbins, {Glenn T.} and Comella, {Cynthia L.} and Peterson, {David A.}",
note = "Funding Information: This research was conducted via the Dystonia Coalition, which is part of the Rare Diseases Clinical Research Network, an initiative funded by the Office of Rare Diseases Research at the National Center for Advancing Translational Sciences (U54 TR001456) in collaboration with the National Institute of Neurological Disorders and Stroke (U54 NS065701 and U54 NS116025) at the National Institute of Health (NIH). This work was also supported by the Office of the Assistant Secretary of Defense for Health Affairs, through the Peer-Reviewed Medical Research Program under Award No. W81XWH-17-1-0393. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense. Publisher Copyright: {\textcopyright} 2021, Springer-Verlag GmbH, DE part of Springer Nature.",
year = "2021",
month = may,
doi = "10.1007/s00415-020-10378-5",
language = "English",
volume = "268",
pages = "1945--1950",
journal = "Journal of Neurology",
issn = "0340-5354",
number = "5",
}