Head-to-Head Comparison of p63 and p40 in Non-Neuroendocrine Carcinomas of the Tubal Gut

Ahmed M. Bakhshwin, Ilyssa O. Gordon, Kathryn Bock Brown, Xiuli Liu, Daniela S. Allende

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objectives.: With targeted agents, characterizing carcinomas of the gastrointestinal (GI) tract has become more important. We aim to determine the usefulness of p40 in classifying GI tract carcinomas. Methods.: Seventy-five GI carcinomas including 28 squamous cell carcinomas (SCC), 2 adenosquamous carcinomas (ASCA), 21 poorly differentiated carcinomas (PDCA), and 24 adenocarcinomas (AdCA; control group) were stained for p40, p63, and CK5/6. Tumors were scored from 0 to 5 based on extent of staining and marked as positive (score >2) or negative. Results.: p63 was positive in 100% of SCC/ASCA and 12.5% of AdCA. p40 was positive in 92.5% of SCC/ASCA and 4.1% of AdCA. In the PDCA subset, a panel including p63, p40, and MOC31 was the best way to accurately classify most cases. Conclusions.: p63 and CK5/6 are more sensitive but less specific than p40 for SCC/ASCA in GI carcinomas. In PDCA, a panel approach including p63, CK5/6, and p40 may be best in classifying these cases.

Original languageEnglish
Pages (from-to)835-843
Number of pages9
JournalInternational Journal of Surgical Pathology
Issue number8
StatePublished - Dec 1 2020


  • anal cancer
  • CK5/6
  • deltaNp63/p40
  • esophageal cancer
  • gastrointestinal
  • immunohistochemistry
  • p63
  • poorly differentiated carcinoma
  • squamous cell carcinoma


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