TY - JOUR
T1 - Head-Mounted Devices for Noninvasive Cancer Imaging and Intraoperative Image-Guided Surgery
AU - Mondal, Suman B.
AU - Tsen, Shaw Wei D.
AU - Achilefu, Samuel
N1 - Funding Information:
This research was supported in part by the National Institutes of Health grants (R01 CA171651, U54 CA199092, R01 EB021048, P50 CA094056, P30 CA091842, S10 OD020129, S10 OD016237, and S10 RR031625), the Department of Defense Breast Cancer Research Program (W81XWH-16-1-0286), and the Alvin J. Siteman Cancer Center Investment Program Research Development Award.
Funding Information:
This research was supported in part by the National Institutes of Health grants (R01 CA171651, U54 CA199092, R01 EB021048, P50 CA094056, P30 CA091842, S10 OD020129, S10 OD016237, and S10 RR031625), the Department of Defense Breast Cancer Research Program (W81XWH‐16‐1‐0286), and the Alvin J. Siteman Cancer Center Investment Program Research Development Award.
Publisher Copyright:
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Medical imaging methods have improved the detection of human diseases with increasing accuracy. The ability to probe molecular processes noninvasively or using tissue-selective imaging agents and nanoparticles has made it possible to localize, identify the stage, and determine the functional status of pathological lesions. The challenges in detecting cancer particularly have driven the development of diverse imaging technologies. While earlier cancer imaging methods enabled preoperative evaluation, the need to track and visualize cancer location in the operating room itself has ushered in new systems capable of providing concurrent images of cancer during surgery. Intraoperative use of conventional clinical imaging modalities is often limited by bulky hardware design, prohibitive cost, lack of real-time image display, and compatibility with conventional hardware interfaces. For these reasons, focus on fluorescence-guided surgery (FGS) devices has increased to take advantage of real-time, high-resolution, functional imaging with hardware that has become increasingly amenable to miniaturization. In particular, the adaptation of wearable devices for FGS presents hands-free capability for optimal navigation during cancer surgery. The evolution of head-mounted devices in the operating room and adaptation for FGS is highlighted. Key challenges to wide clinical adoption of this imaging platform are identified and potential future directions are suggested.
AB - Medical imaging methods have improved the detection of human diseases with increasing accuracy. The ability to probe molecular processes noninvasively or using tissue-selective imaging agents and nanoparticles has made it possible to localize, identify the stage, and determine the functional status of pathological lesions. The challenges in detecting cancer particularly have driven the development of diverse imaging technologies. While earlier cancer imaging methods enabled preoperative evaluation, the need to track and visualize cancer location in the operating room itself has ushered in new systems capable of providing concurrent images of cancer during surgery. Intraoperative use of conventional clinical imaging modalities is often limited by bulky hardware design, prohibitive cost, lack of real-time image display, and compatibility with conventional hardware interfaces. For these reasons, focus on fluorescence-guided surgery (FGS) devices has increased to take advantage of real-time, high-resolution, functional imaging with hardware that has become increasingly amenable to miniaturization. In particular, the adaptation of wearable devices for FGS presents hands-free capability for optimal navigation during cancer surgery. The evolution of head-mounted devices in the operating room and adaptation for FGS is highlighted. Key challenges to wide clinical adoption of this imaging platform are identified and potential future directions are suggested.
KW - cancer
KW - contrast agents
KW - fluorescence imaging
KW - head-mounted displays
KW - optical imaging
KW - surgery
UR - http://www.scopus.com/inward/record.url?scp=85084207257&partnerID=8YFLogxK
U2 - 10.1002/adfm.202000185
DO - 10.1002/adfm.202000185
M3 - Review article
AN - SCOPUS:85084207257
VL - 30
JO - Advanced Functional Materials
JF - Advanced Functional Materials
SN - 1616-301X
IS - 37
M1 - 2000185
ER -