TY - JOUR
T1 - HDL Composition, Heart Failure, and Its Comorbidities
AU - Diab, Ahmed
AU - Valenzuela Ripoll, Carla
AU - Guo, Zhen
AU - Javaheri, Ali
N1 - Publisher Copyright:
Copyright © 2022 Diab, Valenzuela Ripoll, Guo and Javaheri.
PY - 2022/3/8
Y1 - 2022/3/8
N2 - Although research on high-density lipoprotein (HDL) has historically focused on atherosclerotic coronary disease, there exists untapped potential of HDL biology for the treatment of heart failure. Anti-oxidant, anti-inflammatory, and endothelial protective properties of HDL could impact heart failure pathogenesis. HDL-associated proteins such as apolipoprotein A-I and M may have significant therapeutic effects on the myocardium, in part by modulating signal transduction pathways and sphingosine-1-phosphate biology. Furthermore, because heart failure is a complex syndrome characterized by multiple comorbidities, there are complex interactions between heart failure, its comorbidities, and lipoprotein homeostatic mechanisms. In this review, we will discuss the effects of heart failure and associated comorbidities on HDL, explore potential cardioprotective properties of HDL, and review novel HDL therapeutic targets in heart failure.
AB - Although research on high-density lipoprotein (HDL) has historically focused on atherosclerotic coronary disease, there exists untapped potential of HDL biology for the treatment of heart failure. Anti-oxidant, anti-inflammatory, and endothelial protective properties of HDL could impact heart failure pathogenesis. HDL-associated proteins such as apolipoprotein A-I and M may have significant therapeutic effects on the myocardium, in part by modulating signal transduction pathways and sphingosine-1-phosphate biology. Furthermore, because heart failure is a complex syndrome characterized by multiple comorbidities, there are complex interactions between heart failure, its comorbidities, and lipoprotein homeostatic mechanisms. In this review, we will discuss the effects of heart failure and associated comorbidities on HDL, explore potential cardioprotective properties of HDL, and review novel HDL therapeutic targets in heart failure.
KW - apolipoprotein A-I
KW - apolipoprotein M
KW - cardiomyopathy
KW - heart failure
KW - high-density lipoprotein (HDL)
KW - sphingosine-1-phosphate
UR - http://www.scopus.com/inward/record.url?scp=85130854020&partnerID=8YFLogxK
U2 - 10.3389/fcvm.2022.846990
DO - 10.3389/fcvm.2022.846990
M3 - Review article
C2 - 35350538
AN - SCOPUS:85130854020
SN - 2297-055X
VL - 9
JO - Frontiers in Cardiovascular Medicine
JF - Frontiers in Cardiovascular Medicine
M1 - 846990
ER -