@article{dc14b4f0aecc4b5b87ef9233ce6a7afb,
title = "HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies",
abstract = "Slaughter et al. use proteomic and genomic approaches to quantitatively assess the impact of histone deacetylase inhibitor (HDACi) treatment on histone acetylation and BRD4 binding genome-wide. Their studies show that HDACi treatment causes histone polyacetylation and recruitment of BRD4, particularly in the gene bodies of actively transcribed genes.",
keywords = "BRD4, HDAC, bromodomain, chromatin immunoprecipitation, histone acetylation, mass spectrometry, peptide microarray, superenhancer, transcription",
author = "Slaughter, {Mariesa J.} and Shanle, {Erin K.} and Abid Khan and Chua, {Katrin F.} and Tao Hong and Boxer, {Lisa D.} and Allis, {C. David} and Josefowicz, {Steven Z.} and Garcia, {Benjamin A.} and Rothbart, {Scott B.} and Strahl, {Brian D.} and Davis, {Ian J.}",
note = "Funding Information: This work was funded, in part, through a University Cancer Research Fund pilot grant from the Lineberger Comprehensive Cancer Center to B.D.S. and I.J.D. and from grants from the NIH to B.D.S. (GM12690), I.J.D (CA198482), and S.B.R. (GM124736). We also thank Alexey Soshnev for assistance in creating the schematic in the Graphical Abstract and Figure 2C. B.D.S. I.J.D. and S.B.R. conceived the study. E.K.S. performed ChIP-seq experiments. and A.K. performed RNA-seq experiments and chromatin fractionations. M.J.S. analyzed ChIP-seq and RNA-seq data. K.F.C. T.H. and L.D.B. generated bromodomains used for the peptide arrays. C.D.A. B.A.G. and S.Z.J. performed mass spectrometry experiments. S.B.R. and E.K.S. performed bromodomain microarrays. M.J.S. E.K.S. I.J.D. and B.D.S. wrote and edited the manuscript. B.D.S. is a cofounder and scientific advisory board member of EpiCypher, Inc. and a scientific advisory board member of Triangle Biotechnology, Inc. I.J.D. is a scientific advisory board member of Triangle Biotechnology, Inc. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2021",
month = jan,
day = "19",
doi = "10.1016/j.celrep.2020.108638",
language = "English",
volume = "34",
journal = "Cell Reports",
issn = "2211-1247",
number = "3",
}