HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies

Mariesa J. Slaughter, Erin K. Shanle, Abid Khan, Katrin F. Chua, Tao Hong, Lisa D. Boxer, C. David Allis, Steven Z. Josefowicz, Benjamin A. Garcia, Scott B. Rothbart, Brian D. Strahl, Ian J. Davis

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Slaughter et al. use proteomic and genomic approaches to quantitatively assess the impact of histone deacetylase inhibitor (HDACi) treatment on histone acetylation and BRD4 binding genome-wide. Their studies show that HDACi treatment causes histone polyacetylation and recruitment of BRD4, particularly in the gene bodies of actively transcribed genes.

Original languageEnglish
Article number108638
JournalCell Reports
Volume34
Issue number3
DOIs
StatePublished - Jan 19 2021

Keywords

  • BRD4
  • HDAC
  • bromodomain
  • chromatin immunoprecipitation
  • histone acetylation
  • mass spectrometry
  • peptide microarray
  • superenhancer
  • transcription

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