Harnessing the intrinsic photochemistry of isoxazoles for the development of chemoproteomic crosslinking methods

Marshall G. Lougee; Vinayak Vishnu Pagar; Hee Jong Kim; Samantha X. Pancoe; W. Kit Chia; Robert H. Mach; Benjamin A. Garcia; E. James Petersson

doi:10.1039/d2cc02263j

Harnessing the intrinsic photochemistry of isoxazoles for the development of chemoproteomic crosslinking methods

Marshall G. Lougee
, Vinayak Vishnu Pagar
, Hee Jong Kim
, Samantha X. Pancoe
, W. Kit Chia
, Robert H. Mach
, Benjamin A. Garcia
, E. James Petersson

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The intrinsic photochemistry of the isoxazole, a common heterocycle in medicinal chemistry, can be applied to offer an alternative to existing strategies using more perturbing, extrinsic photo-crosslinkers. The utility of isoxazole photo-crosslinking is demonstrated in a wide range of biologically relevant experiments, including common proteomics workflows.

Original language	English
Pages (from-to)	9116-9119
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	65
DOIs	https://doi.org/10.1039/d2cc02263j
State	Published - Jul 26 2022

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10.1039/d2cc02263j

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abstract = "The intrinsic photochemistry of the isoxazole, a common heterocycle in medicinal chemistry, can be applied to offer an alternative to existing strategies using more perturbing, extrinsic photo-crosslinkers. The utility of isoxazole photo-crosslinking is demonstrated in a wide range of biologically relevant experiments, including common proteomics workflows.",

author = "Lougee, \{Marshall G.\} and Pagar, \{Vinayak Vishnu\} and Kim, \{Hee Jong\} and Pancoe, \{Samantha X.\} and Chia, \{W. Kit\} and Mach, \{Robert H.\} and Garcia, \{Benjamin A.\} and Petersson, \{E. James\}",

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doi = "10.1039/d2cc02263j",

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AU - Lougee, Marshall G.

AU - Pagar, Vinayak Vishnu

AU - Kim, Hee Jong

AU - Pancoe, Samantha X.

AU - Chia, W. Kit

AU - Mach, Robert H.

AU - Garcia, Benjamin A.

AU - Petersson, E. James

PY - 2022/7/26

Y1 - 2022/7/26

N2 - The intrinsic photochemistry of the isoxazole, a common heterocycle in medicinal chemistry, can be applied to offer an alternative to existing strategies using more perturbing, extrinsic photo-crosslinkers. The utility of isoxazole photo-crosslinking is demonstrated in a wide range of biologically relevant experiments, including common proteomics workflows.

AB - The intrinsic photochemistry of the isoxazole, a common heterocycle in medicinal chemistry, can be applied to offer an alternative to existing strategies using more perturbing, extrinsic photo-crosslinkers. The utility of isoxazole photo-crosslinking is demonstrated in a wide range of biologically relevant experiments, including common proteomics workflows.

UR - https://www.scopus.com/pages/publications/85135216633

U2 - 10.1039/d2cc02263j

DO - 10.1039/d2cc02263j

M3 - Article

C2 - 35880535

AN - SCOPUS:85135216633

SN - 1359-7345

VL - 58

SP - 9116

EP - 9119

JO - Chemical Communications

JF - Chemical Communications

IS - 65

ER -

Harnessing the intrinsic photochemistry of isoxazoles for the development of chemoproteomic crosslinking methods

Abstract

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