Harnessing the intrinsic photochemistry of isoxazoles for the development of chemoproteomic crosslinking methods

Marshall G. Lougee, Vinayak Vishnu Pagar, Hee Jong Kim, Samantha X. Pancoe, W. Kit Chia, Robert H. Mach, Benjamin A. Garcia, E. James Petersson

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The intrinsic photochemistry of the isoxazole, a common heterocycle in medicinal chemistry, can be applied to offer an alternative to existing strategies using more perturbing, extrinsic photo-crosslinkers. The utility of isoxazole photo-crosslinking is demonstrated in a wide range of biologically relevant experiments, including common proteomics workflows.

Original languageEnglish
Pages (from-to)9116-9119
Number of pages4
JournalChemical Communications
Volume58
Issue number65
DOIs
StatePublished - Jul 26 2022

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