Harnessing the intrinsic photochemistry of isoxazoles for the development of chemoproteomic crosslinking methods

Marshall G. Lougee; Vinayak Vishnu Pagar; Hee Jong Kim; Samantha X. Pancoe; W. Kit Chia; Robert H. Mach; Benjamin A. Garcia; E. James Petersson

doi:10.1039/d2cc02263j

Harnessing the intrinsic photochemistry of isoxazoles for the development of chemoproteomic crosslinking methods

Marshall G. Lougee, Vinayak Vishnu Pagar, Hee Jong Kim, Samantha X. Pancoe, W. Kit Chia, Robert H. Mach, Benjamin A. Garcia, E. James Petersson

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6 Scopus citations

Abstract

The intrinsic photochemistry of the isoxazole, a common heterocycle in medicinal chemistry, can be applied to offer an alternative to existing strategies using more perturbing, extrinsic photo-crosslinkers. The utility of isoxazole photo-crosslinking is demonstrated in a wide range of biologically relevant experiments, including common proteomics workflows.

Original language	English
Pages (from-to)	9116-9119
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	65
DOIs	https://doi.org/10.1039/d2cc02263j
State	Published - Jul 26 2022

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abstract = "The intrinsic photochemistry of the isoxazole, a common heterocycle in medicinal chemistry, can be applied to offer an alternative to existing strategies using more perturbing, extrinsic photo-crosslinkers. The utility of isoxazole photo-crosslinking is demonstrated in a wide range of biologically relevant experiments, including common proteomics workflows.",

author = "Lougee, {Marshall G.} and Pagar, {Vinayak Vishnu} and Kim, {Hee Jong} and Pancoe, {Samantha X.} and Chia, {W. Kit} and Mach, {Robert H.} and Garcia, {Benjamin A.} and Petersson, {E. James}",

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AU - Lougee, Marshall G.

AU - Pagar, Vinayak Vishnu

AU - Kim, Hee Jong

AU - Pancoe, Samantha X.

AU - Chia, W. Kit

AU - Mach, Robert H.

AU - Garcia, Benjamin A.

AU - Petersson, E. James

PY - 2022/7/26

Y1 - 2022/7/26

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AB - The intrinsic photochemistry of the isoxazole, a common heterocycle in medicinal chemistry, can be applied to offer an alternative to existing strategies using more perturbing, extrinsic photo-crosslinkers. The utility of isoxazole photo-crosslinking is demonstrated in a wide range of biologically relevant experiments, including common proteomics workflows.

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DO - 10.1039/d2cc02263j

M3 - Article

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AN - SCOPUS:85135216633

SN - 1359-7345

VL - 58

SP - 9116

EP - 9119

JO - Chemical Communications

JF - Chemical Communications

IS - 65

ER -

Harnessing the intrinsic photochemistry of isoxazoles for the development of chemoproteomic crosslinking methods

Abstract

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