Harnessing the DNA Repair Pathway in Breast Cancer: Germline Mutations/Polymorphisms in Breast Radiation

Michael D. Green, Randall Brenneman, Simon N. Powell, Carmen Bergom

Research output: Contribution to journalReview articlepeer-review

Abstract

Molecular profiling facilitates opportunities for personalization of breast cancer management. Increasing availability of germline and somatic sequencing provides insight into predictors of treatment efficacy and treatment tolerance of patients with breast cancer. The presence of pathologic mutations can guide patient selection for breast conserving surgery vs mastectomy. However, our understanding of the interplay between genetic variants and radiotherapy responses and side effects remains incomplete. Here we review the available data on germline mutations and polymorphisms in breast cancer. We also outline their association with treatment tolerance, locoregional outcomes, and ongoing efforts to transform these insights into more effective treatment strategies in combination with radiotherapy.

Original languageEnglish
Pages (from-to)298-302
Number of pages5
JournalSeminars in Radiation Oncology
Volume32
Issue number3
DOIs
StatePublished - Jul 2022

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