Harnessing technologies to unravel gastric cancer heterogeneity

Yuefan Wang; Ramon U. Jin; Joanne Xu; Ding Chiao Lin; Zhenyu Sun; Yuanwei Xu; Qing K. Li; Hui Zhang

doi:10.1016/j.trecan.2025.04.011

Harnessing technologies to unravel gastric cancer heterogeneity

Yuefan Wang, Ramon U. Jin, Joanne Xu, Ding Chiao Lin, Zhenyu Sun, Yuanwei Xu, Qing K. Li, Hui Zhang

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Gastric cancer arises from complex carcinogenic factor interactions, with limited treatment options due to the lack of targetable driver gene mutations and significant tumor heterogeneity. Recent studies have provided promising novel approaches to improve our understanding of gastric cancer heterogeneity through integrated characterization, combining genomics with emerging technologies. Delineating the molecular changes and targeting specific molecular subtypes will enhance the efficacy of gastric cancer treatment and improve clinical outcomes. This review provides a comprehensive overview of current technologies used in gastric cancer research, highlighting key discoveries and treatment strategies driven by these innovations. Finally, we discuss the emerging technology-guided directions and potential breakthroughs that could enhance the understanding of gastric cancer tumor heterogeneity, ultimately improving clinical outcomes.

Original language	English
Pages (from-to)	753-769
Number of pages	17
Journal	Trends in Cancer
Volume	11
Issue number	8
DOIs	https://doi.org/10.1016/j.trecan.2025.04.011
State	Published - Aug 2025

Keywords

gastric cancer
multi-omics technology
single-cell analysis
tumor heterogeneity

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10.1016/j.trecan.2025.04.011

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title = "Harnessing technologies to unravel gastric cancer heterogeneity",

abstract = "Gastric cancer arises from complex carcinogenic factor interactions, with limited treatment options due to the lack of targetable driver gene mutations and significant tumor heterogeneity. Recent studies have provided promising novel approaches to improve our understanding of gastric cancer heterogeneity through integrated characterization, combining genomics with emerging technologies. Delineating the molecular changes and targeting specific molecular subtypes will enhance the efficacy of gastric cancer treatment and improve clinical outcomes. This review provides a comprehensive overview of current technologies used in gastric cancer research, highlighting key discoveries and treatment strategies driven by these innovations. Finally, we discuss the emerging technology-guided directions and potential breakthroughs that could enhance the understanding of gastric cancer tumor heterogeneity, ultimately improving clinical outcomes.",

keywords = "gastric cancer, multi-omics technology, single-cell analysis, tumor heterogeneity",

author = "Yuefan Wang and Jin, \{Ramon U.\} and Joanne Xu and Lin, \{Ding Chiao\} and Zhenyu Sun and Yuanwei Xu and Li, \{Qing K.\} and Hui Zhang",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Inc.",

year = "2025",

month = aug,

doi = "10.1016/j.trecan.2025.04.011",

language = "English",

volume = "11",

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T1 - Harnessing technologies to unravel gastric cancer heterogeneity

AU - Wang, Yuefan

AU - Jin, Ramon U.

AU - Xu, Joanne

AU - Lin, Ding Chiao

AU - Sun, Zhenyu

AU - Xu, Yuanwei

AU - Li, Qing K.

AU - Zhang, Hui

PY - 2025/8

Y1 - 2025/8

N2 - Gastric cancer arises from complex carcinogenic factor interactions, with limited treatment options due to the lack of targetable driver gene mutations and significant tumor heterogeneity. Recent studies have provided promising novel approaches to improve our understanding of gastric cancer heterogeneity through integrated characterization, combining genomics with emerging technologies. Delineating the molecular changes and targeting specific molecular subtypes will enhance the efficacy of gastric cancer treatment and improve clinical outcomes. This review provides a comprehensive overview of current technologies used in gastric cancer research, highlighting key discoveries and treatment strategies driven by these innovations. Finally, we discuss the emerging technology-guided directions and potential breakthroughs that could enhance the understanding of gastric cancer tumor heterogeneity, ultimately improving clinical outcomes.

AB - Gastric cancer arises from complex carcinogenic factor interactions, with limited treatment options due to the lack of targetable driver gene mutations and significant tumor heterogeneity. Recent studies have provided promising novel approaches to improve our understanding of gastric cancer heterogeneity through integrated characterization, combining genomics with emerging technologies. Delineating the molecular changes and targeting specific molecular subtypes will enhance the efficacy of gastric cancer treatment and improve clinical outcomes. This review provides a comprehensive overview of current technologies used in gastric cancer research, highlighting key discoveries and treatment strategies driven by these innovations. Finally, we discuss the emerging technology-guided directions and potential breakthroughs that could enhance the understanding of gastric cancer tumor heterogeneity, ultimately improving clinical outcomes.

KW - gastric cancer

KW - multi-omics technology

KW - single-cell analysis

KW - tumor heterogeneity

UR - https://www.scopus.com/pages/publications/105006757619

U2 - 10.1016/j.trecan.2025.04.011

DO - 10.1016/j.trecan.2025.04.011

M3 - Review article

C2 - 40425443

AN - SCOPUS:105006757619

SN - 2405-8033

VL - 11

SP - 753

EP - 769

JO - Trends in Cancer

JF - Trends in Cancer

IS - 8

ER -

Harnessing technologies to unravel gastric cancer heterogeneity

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Keywords

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