Harnessing Natural Killer Cell Function for Genitourinary Cancers

Nina Bhardwaj, Adam M. Farkas, Zeynep Gul, John P. Sfakianos

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Natural killer (NK) cells are potently cytolytic innate lymphocytes involved in the immune surveillance of tumors and virally infected cells. Although much progress has been made in manipulating the ability of T cells to recognize and eliminate tumors, a comprehensive understanding of NK-cell infiltration into solid tumors, and their amenability to immunomodulation, remains incomplete. This article discusses recent studies showing that urologic tumors are infiltrated by NK cells and that these NK cells are often dysfunctional, but that strategies interfering with inhibitory axes have significant potential to alleviate this dysfunction.

Original languageEnglish
Pages (from-to)433-442
Number of pages10
JournalUrologic Clinics of North America
Volume47
Issue number4
DOIs
StatePublished - Nov 2020

Keywords

  • Bladder cancer
  • Genitourinary cancer
  • Immunotherapy
  • Natural killer cells
  • NK cells
  • RCC
  • Renal cancer

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