Hardly Vacuous: The Parasitophorous Vacuolar Membrane of Malaria Parasites

Daniel E. Goldberg, Joshua Zimmerberg

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

When a malaria parasite invades a host erythrocyte it pushes itself in and invaginates a portion of the host membrane, thereby sealing itself inside and establishing itself in the resulting vacuole. The parasitophorous vacuolar membrane (PVM) that surrounds the parasite is modified by the parasite, using its secretory organelles. To survive within this enveloping membrane, the organism must take in nutrients, secrete wastes, export proteins into the host cell, and eventually egress. Here, we review current understanding of the unique solutions Plasmodium has evolved to these challenges and discuss the remaining questions.

Original languageEnglish
Pages (from-to)138-146
Number of pages9
JournalTrends in Parasitology
Volume36
Issue number2
DOIs
StatePublished - Feb 2020

Keywords

  • Plasmodium
  • parasitophorous vacuole

Fingerprint

Dive into the research topics of 'Hardly Vacuous: The Parasitophorous Vacuolar Membrane of Malaria Parasites'. Together they form a unique fingerprint.

Cite this