TY - JOUR
T1 - Hardly Vacuous
T2 - The Parasitophorous Vacuolar Membrane of Malaria Parasites
AU - Goldberg, Daniel E.
AU - Zimmerberg, Joshua
N1 - Funding Information:
Illustrations were provided by Abigail Kimball in association with InPrint at Washington University in St Louis, USA. This work is funded in part by the Division of Intramural Research of the NICHD.
Publisher Copyright:
© 2019 The Author(s)
PY - 2020/2
Y1 - 2020/2
N2 - When a malaria parasite invades a host erythrocyte it pushes itself in and invaginates a portion of the host membrane, thereby sealing itself inside and establishing itself in the resulting vacuole. The parasitophorous vacuolar membrane (PVM) that surrounds the parasite is modified by the parasite, using its secretory organelles. To survive within this enveloping membrane, the organism must take in nutrients, secrete wastes, export proteins into the host cell, and eventually egress. Here, we review current understanding of the unique solutions Plasmodium has evolved to these challenges and discuss the remaining questions.
AB - When a malaria parasite invades a host erythrocyte it pushes itself in and invaginates a portion of the host membrane, thereby sealing itself inside and establishing itself in the resulting vacuole. The parasitophorous vacuolar membrane (PVM) that surrounds the parasite is modified by the parasite, using its secretory organelles. To survive within this enveloping membrane, the organism must take in nutrients, secrete wastes, export proteins into the host cell, and eventually egress. Here, we review current understanding of the unique solutions Plasmodium has evolved to these challenges and discuss the remaining questions.
KW - Plasmodium
KW - parasitophorous vacuole
UR - http://www.scopus.com/inward/record.url?scp=85076954039&partnerID=8YFLogxK
U2 - 10.1016/j.pt.2019.11.006
DO - 10.1016/j.pt.2019.11.006
M3 - Review article
C2 - 31866184
AN - SCOPUS:85076954039
SN - 1471-4922
VL - 36
SP - 138
EP - 146
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 2
ER -