Haploidentical bone marrow transplant with posttransplant cyclophosphamide for sickle cell disease: An update

Dilan A. Patel, Adeseye M. Akinsete, Josu de la Fuente, Adetola A. Kassim

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Hematopoietic cell transplant (HCT) can cure both children and adults with sickle cell disease. Outcomes have historically been poor for the vast majority of patients who lack a matched sibling donor. However, the development of haploidentical HCT (haplo-HCT) with high doses of posttransplant cyclophosphamide (PTCy) has allowed for curative long-term potential with favorable transplant-related outcomes, though this has not obviated the potential for graft rejection from human leukocyte antigen mismatch and repeated red blood cell transfusions. Accordingly, multiple strategies have been developed to improve outcomes, the majority of which are based on the Johns Hopkins platform from 2012. Presently, we aim to discuss results from pertinent studies and compare outcomes with the two most recent approaches involving either thiotepa plus 200-cGy total body irradiation or 400-cGy total body irradiation. Direct comparisons are required to determine the optimized curative potential. Transplant-eligible patients must be referred to tertiary medical centers for consideration of haplo-HCT.

Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalHematology/ Oncology and Stem Cell Therapy
Volume13
Issue number2
DOIs
StatePublished - Jun 2020

Keywords

  • Cyclophosphamide
  • Haploidentical transplant
  • Sickle cell disease
  • Thiotepa
  • Total body irradiation

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