Hantavirus Cardiopulmonary Syndrome Due to Imported Andes Hantavirus Infection in Switzerland: A Multidisciplinary Challenge, Two Cases and a Literature Review

Andrea B. Kuenzli, Jonas Marschall, Joerg C. Schefold, Margaret Schafer, Oliver B. Engler, Rahel Ackermann-Gäumann, David C. Reineke, Franziska Suter-Riniker, Cornelia Staehelin

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Two travellers returning from South America were diagnosed with Andes hantavirus infection, the only member of the Hantaviridae family known to be transmitted from person to person. We describe the clinical course and therapeutic and infection control measures. While both patients showed high viral load (VL) and shedding over several months, 1 patient recovered within 1 week from severe respiratory illness that required noninvasive ventilation, whereas the second patient developed severe hantavirus cardiopulmonary syndrome that required extracorporeal membrane oxygenation for 27 days. The clinical course in the latter patient was complicated by severe disseminated intravascular coagulopathy with diffuse hemorrhage that necessitated mass transfusions, as well as by multiple organ failure, including the need for renal replacement therapy. Results of VL in blood, respiratory secretions, and semen for the first 9 months of follow-up are reported. To our knowledge, these are the first cases of Andes hantavirus infection detected in Europe.

Original languageEnglish
Pages (from-to)1796-1797
Number of pages2
JournalClinical Infectious Diseases
Volume67
Issue number11
DOIs
StatePublished - Nov 13 2018

Keywords

  • American hantavirus
  • Andes hantavirus
  • ECMO
  • hantavirus cardiopulmonary syndrome
  • hemorrhagic fever

Fingerprint

Dive into the research topics of 'Hantavirus Cardiopulmonary Syndrome Due to Imported Andes Hantavirus Infection in Switzerland: A Multidisciplinary Challenge, Two Cases and a Literature Review'. Together they form a unique fingerprint.

Cite this