Handheld photoacoustic microscopy to detect melanoma depth in vivo

Yong Zhou, Wenxin Xing, Konstantin I. Maslov, Lynn A. Cornelius, Lihong V. Wang

Research output: Contribution to journalArticlepeer-review

86 Scopus citations


We developed handheld photoacoustic microscopy (PAM) to detect melanoma and determine tumor depth in nude mice in vivo. Compared to our previous PAM system for melanoma imaging, a new light delivery mechanism is introduced to improve light penetration. We show that melanomas with 4.1 and 3.7 mm thicknesses can be successfully detected in phantom and in in vivo experiments, respectively. With its deep melanoma imaging ability and handheld design, this system can be tested for clinical melanoma diagnosis, prognosis, and surgical planning for patients at the bedside.

Original languageEnglish
Pages (from-to)4731-4734
Number of pages4
JournalOptics Letters
Issue number16
StatePublished - 2014


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