Handheld electromagnet carrier for transfer of hyperpolarized carbon-13 samples

Hong Shang, Timothy Skloss, Cornelius Von Morze, Lucas Carvajal, Mark Van Criekinge, Eugene Milshteyn, Peder E.Z. Larson, Ralph E. Hurd, Daniel B. Vigneron

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Purpose Hyperpolarization of carbon-13 (13C) nuclei by dissolution dynamic nuclear polarization increases signal-to-noise ratio (SNR) by >10,000-fold for metabolic imaging, but care must be taken when transferring hyperpolarized (HP) samples from polarizer to MR scanner. Some 13C substrates relax rapidly in low ambient magnetic fields. A handheld electromagnet carrier was designed and constructed to preserve polarization by maintaining a sufficient field during sample transfer. Methods The device was constructed with a solenoidal electromagnet, powered by a nonmagnetic battery, holding the HP sample during transfer. A specially designed switch automated deactivation of the field once transfer was complete. Phantom and rat experiments were performed to compare MR signal enhancement with or without the device for HP [13C]urea and [1-13C]pyruvate. Results The magnetic field generated by this device was tested to be >50 G over a 6-cm central section. In phantom and rat experiments, [13C]urea transported via the device showed SNR improvement by a factor of 1.8-1.9 over samples transferred through the background field. Conclusion A device was designed and built to provide a suitably high yet safe magnetic field to preserve hyperpolarization during sample transfer. Comparative testing demonstrated SNR improvements of approximately two-fold for [13C]urea while maintaining SNR for [1-13C]pyruvate.

Original languageEnglish
Pages (from-to)917-922
Number of pages6
JournalMagnetic resonance in medicine
Volume75
Issue number2
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

Keywords

  • T1 relaxation
  • dynamic nuclear polarization
  • hyperpolarized carbon-13 MRI/MRSI
  • low magnetic field
  • scalar coupling
  • urea

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    Shang, H., Skloss, T., Von Morze, C., Carvajal, L., Van Criekinge, M., Milshteyn, E., Larson, P. E. Z., Hurd, R. E., & Vigneron, D. B. (2016). Handheld electromagnet carrier for transfer of hyperpolarized carbon-13 samples. Magnetic resonance in medicine, 75(2), 917-922. https://doi.org/10.1002/mrm.25657